Professor

Phone: (0086)-027-83692745(O)

Email: xiangming@mails.tjmu.edu.cn

Academic Areas: Pharmacology

Research Interests: Focus on pathogenesis study of autoimmune diseases, including T1D,RA, AIH and chronic inflammation (pancreatitis, diabetic nephropathy and insulin resistance); investigate the induction of antigen-specific immune tolerance

Academic Degrees

PhD in Institute of Environmental Medicine College of Public Health, Tongji Medical College, 2005, Huazhong Univ Sci Tech, Wuhan, China;

MD in Dept. of Pharmacology, School of Pharmaceutical Science, Tongji Medical Univ, 1993, Huazhong Univ Sci Tech, Wuhan, China;

BA in School of Pharmaceutical Science, Tongji Medical Univ, 1990, Wuhan, China

Professional Experience

Professor (2007-present); School of Pharmaceutical Science, Tongji Medical College, HUST

Professor (2010-2010); Biomedical Center, College of Georgia, USA

Associate Professor (2004-2005); Otto-Mayor-Centrum, Department of Internal Medicine IV, University of Heidelberg, Germany

Lecturer (1997-1999); Dept. of Microbiology, University of Catania, Italy

Selected Publications

1.Xiang M, Liu T, Tan W, Ren H, Li H, Liu J, Cao H, Cheng Q, Liu X, Zhu H, Tuo Y, Wang J, Zhang Y. Effects of kinsenoside, a potential immunosuppressive drug for autoimmune hepatitis, on DCs-CD8+T cells communication. Hepatology. 2016 Dec 64(6):2135-2150. doi: 10.1002/hep.28825

2. Xia F, Cao H, Du J, Liu X, Liu Y, Xiang M*. Reg3g overexpression promotes β cell regeneration and induces immune tolerance in nonobese-diabetic mouse model. J Leukoc Biol. 2016 Jun;99(6):1131-40. doi: 0.1189/jlb.3A0815-371RRR. (*corresponding author)

3. Xu QQ, Fu R, Yin GX, Liu XL, Liu Y, Xiang M*. Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells. Gene.2016 Mar 10;578(2):263-73. doi:10.1016/j.gene.2015.12.039.

4. Yin G, Du J, Cao H, Liu X, Xu Q, Xiang Ming*. Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis. Digest Dis Sci. 2015 Dec; 60(12):3656-68. doi: 10.1007/s10620-015-3787-5.

5. Cao H, Lu J, Du J, Xia F, Wei S, Liu X, Liu T, Liu Y, Xiang M*. TAK1 inhibition prevents the development of autoimmune diabetes in NOD mice.Sci Rep. 2015 Oct 13;5:14593. doi: 10.1038/srep14593.

6. Cao H, Ji Y, Li W, Liu Y, Fu R, Xiang M*. Protective effects of the total coumarin fraction of urticadentata on experimental diabetic nephropathy in vitro and in vivo. Planta Med. 2015 Oct;81(15):1353-60.

7. Liu T, Cao H, Ji Y, Pei Y, Yu Z,Quan Y*,Xiang M*.Interaction of dendritic cells and T lymphocytes for the therapeutic effect of Dangguiliuhuang decoction to autoimmune diabetes. Sci Rep. 2015 Sep 11;5:13982. doi: 10.1038/srep13982.

8.     Liu X, Wang J, Wang H, Yin G, Liu Y, Lei X, Xiang M*. REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop.Cancer Lett. 2015 Jun 28;362(1):45-60.

9. Wang J, Cao H, Wang H, Yin G, Du J, Xia F, Lu J, Xiang M*.Multiple mechanisms involved in diabetes protection by lipopolysaccharide in non-obese diabetic mice. Toxicol Appl Pharmacol. 2015 Jun 15;285(3):149-58. doi: .1016 /j.taap.2015.04.006.

10. Wang J, Zhou H, Han Y, Liu X, Wang M, Wang X, Yin G, Li X, Xiang M*. SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer.J Mol Med. 2014 Jul 5; 92(12):1257-69.

11. Wang J, Xiang M*.Targeting potassium channels Kv1.3 and KC a 3.1: routes to selective immune modulators in autoimmune disorder treatment? Pharmacotherapy. 2013 May;33(5):515-28.

12. Wang J, Lu J, Lan Y, Zhou H, Li W, Xiang M*.Total coumarins from Urticadentata Hand prevent murine autoimmune diabetes via suppression of the TLR4-signaling pathways. J Ethnopharmacol. 2013 Mar 7;146(1):379-92.

13. Xiang M, Lu J, Zhang C, Lan Y, Zhou H, Li X, Peng W. Identification and quantification of total coumarins from Urticadentata Hand and its roles in promoting immune tolerance via TLR4-mediated dendritic cell immaturation. Biosci Biotechnol Biochem. 2013 Jun 23;77(6):1200-6.

14. Xie S, Feng J, Yu C, Li Z, Wu Y, Cao Z, Li W, He X, Xiang M*, Han S. Identification of a new specific Kv1.3 channel blocker, Ctri9577, from the scorpion Chaerilustricostatus. Peptides. 2012 Jul;36(1):94-9.

15. Lu J, Zeng Y, Hou W, Zhang S, Li L, Luo X, Xi W, Chen Z, Xiang M*. The soybean peptide aglycin regulates glucose homeostasis in type 2 diabetic mice via IR/IRS1 pathway. J Nutr Biochem. 2012; 23(11):1449-57.

16. Xiang M, Zhang S, Lu J, Li L, Hou W, Xie M, Zeng Y. Antilithic effects ofextracts from Urticadentata hand on calcium oxalate urinary stones in rats. J Huazhong Univ Sci Technol. 2011; 31(5): 673-677.

17. Luo X, Li LL, Zhang SS, Lu JL, Zeng Y, Zhang HY, Xiang M*. Therapeutic effects of total coumarins from Urticadentata Hand on collagen-induced arthritis in Balb/c mice. J Ethnopharmacol. 2011; 138(2): 523-9.

18. Hou WR, Xie SN, Xiang M*, et al. Intramuscular delivery of a naked DNA plasmid encoding proinsulin and pancreatic regenerating III protein ameliorates type 1 diabetes mellitus. Pharmacological Research. 2011; 63(4): 320-327.

19. Hou WR, Xiang M*, et al. Immunosuppressive constituents from Urticadentata Hand. J Asian Nat Prod Res. 2010; 12(8): 707-13.

20. Xiang M, Hou WR, Xie SN, et al. Immunosuppressive effects of an ethyl acetate extract from Urticadentata Hand on skin allograft rejection. J Ethnopharmacol.  2009; 126: 57-63.

21. Zhang CL, Zou XL, Guan LL, Xu J, Xiang M*. Prevention of Type 1 Diabetes by Immature Dendritic Cells Treated with an Ethanol Extract of Paecilomyceshepiali Chen Mycelium. Methods Find Exp Clin Pharmacol. 2008; 30(6): 421-429.

22. Zou XL, Zhao ZY,Wang YY, Su ZQ, Xiang M*. Diabetogenic T cells induce autoimmune diabetes in BALB/c mice. Chin Med Sci J. 2008; 23(2):88-94.

23. Xiang M, Zou X, Zhang C, Zhao Z, Xu J. Insulin administration confers diabetes-preventive properties to NOD mice derived dendritic cells. Immunopharmacol Immunotoxicol. 2007; 29(3-4): 451-64.

24. Zhang CL, Zou XL, Xiang M*. Immune tolerance induced by adoptive transfer of DCs in IDDM murine model. Acta Pharmacologica Sinica. 2007; 28(1): 98-104

25. Xiang M, Eisenbach C, Lupu CM, Ernst E, Stremmel W,Encke J. Induction of antigen-specific immune responses in vivo after vaccination with dendritic cells transduced with adenoviral vectors encoding hepatitis C virus NS3. Viral Immunology. 2006; 19(2): 210-219.

26. Xiang M, Zhang CL, Zou XL, Cai XH, Peng JB.Roles of dendritic cells and regulatory T cells in autoantigen-induced urine immune tolerance model. World Chinese Journal of Digestive. 2006; 14(7): 687-692.

27. Xiang M, Eisenbach C, Ernst E, Weigand K, Stremmel W, Encke J. Humoral and cellular immune responses elicited by immunization with genetically modified dendritic cells expressing HCVNS3. Hepatology.2005; 42 (4) Suppl.1:248A

28. Nicoletti F, Zaccone P, Xiang M, Magro G, Di Mauro M, Di Marco R, Garotta G, Meroni P. Essential pathogenetic role for interferon (IFN-)gamma in concanavalin -induced T cell-dependent hepatitis: exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein. Cytokine. 2000; 12(4): 315-23.

29. Nicoletti F, Di Marco R, Zaccone P, Xiang M, Magro G, Grasso S, Morrone S, Santoni A, Shoenfeld Y, Garotta G, Meroni P. Dichotomic effects of IFN-gamma on the development of systemic lupus erythematosus-like syndrome in MRL-lpr / lpr mice. Eur J Immunol. 2000; 30(2): 438-47.

30. Di Marco R, Xiang M, Zaccone P, Leonardi C, Franco S, Meroni P, Nicoletti F. Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency. Autoimmunity. 1999; 31(2): 75-83.

31. Xiang M, Zaccone P, Di Marco R, Harris R, Magro G, Di Mauro M, Meroni PL, Garotta G, Nicoletti F. Failure of exogenously administered interferon-gamma or blockage of endogenous interleukin-4 with specific inhibitors to augment the incidence of autoimmune diabetes in male NOD mice. Autoimmunity. 1999; 30(2):71-80.

32. Xiang M, Zaccone P, Di Marco R, Magro G, Di Mauro M, Beltrami B, Meroni PL, Nicoletti F. Prevention by rolipram of concanavalin A-induced T-cell-dependent hepatitis in mice. Eur J Pharmacol. 1999; 367(2-3): 399-404.

Courses Taught

Pharmacology

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