Professor

Phone: (027)83692793

Email: youjiti@mails.tjmu.edu.cn

Academic Areas: Pharmaceutical Science and Medicinal Chemistry

Research Interests: Novel Nano-Drug Delivery System, Drug Design and Synthesis

Academic Degrees

Ph D in  Environmental and Occupational Health,2000,Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Master of Science, Organic Chemistry, 1995, Department of Chemistry, Wuhan University, China

Bachelor of Science, Department of Chemistry, East China Normal University, Shanghai, China

Professional Experience

Professor(2008-present); School of Pharmacy, Tongji Medical College, HUST

Visiting Scholar(2006-2007); The Ohio State University, Columbus, OH, USA

Associate Professor(2003-2008); School of Pharmacy, Tongji Medical College, HUST

Post-Doc (2001-2002);Tuebingen University, Tuebingen, Germany

Lecturer (1997-2003); School of Pharmacy, Tongji Medical College, HUST

Selected Publications

◆ Yongkang Gai#, Lingyi Sun#, Wenqi Hui, Qin Ouyang, Carolyn J. Anderson, Guangya Xiang*, Xiang Ma*, and Dexing Zeng*,New Bifunctional Chelator p‑SCN-PhPr-NE3TA for Copper-64: Synthesis, Peptidomimetic Conjugation, Radiolabeling, and Evaluation for PET Imaging,Inorganic Chemistry,2016,55(14):6892-6901(IF=4.82)

◆ Yao Lu#, Yuhua Wang, Lei Miao, Matthew Haynes, Guangya Xiang*, Leaf Huang*, Exploiting in situ antigen generation and immune modulation to enhance chemotherapy response in advanced melanoma: A combination nanomedicine approach,Cancer Letters,2016,379(1):32–38(IF=5.992)

◆Yongkang Gai, Guangya Xiang, Xiang Ma, Wenqi Hui, Qin Ouyang, Lingyi Sun, Jiule Ding, Jing Sheng, and Dexing Zeng*, Universal Molecular Scaffold for Facile Construction of Multivalent and Multimodal Imaging Probes,Bioconjugate Chemistry,2016,27:515-520(IF=4.513)

◆ Lu, Yao; Miao, Lei; Wang, Yuhua; Xu, Zhenghong; Zhao, Yi; Shen, Youqing; Xiang, Guangya*; Huang, Leaf*,Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model,Molecular Therapy,2016,24(2):364-374(IF=6.938)

◆ Yang, Tan; Zhao, Pengxuan; Rong, Zhao; Li, Bin; Xue, Huiying; You, Jia; He, Chuanchuan; Li, Weijie; He, Xingxing; Lee, Robert J; Ma, Xiang*; Guangya Xiang*,Anti-tumor Efficiency of Lipid-coated Cisplatin Nanoparticles Co-loaded with MicroRNA-375,Theranostics,2016,6(1):142-154(IF=8.854)

◆ Gai, YK;Hu, ZP ; Rong, Z;Ma, X*;Xiang, GY*,A Practical Route for the Preparation of 1,4,7-Triazacyclononanyl Diacetates with a Hydroxypyridinonate Pendant Arm,Molecules,2015,20(10):19393-19405(IF=2.416)

◆ Zhang, Wendian; Peng, Fangqi; Zhou, Taotao; Huang, Yifei; Zhang, Li; Ye, Peng; Lu, Miao; Yang, Guang; Gai, Yongkang; Yang, Tan; Ma, Xiang*; Xiang, Guangya*,Targeted delivery of chemically modified anti-miR-221 to hepatocellular carcinoma with negatively charged liposomes,International Journal of Nanomedicine,  2015,10:4825-4836. (IF=4.195)

◆  Yifei Huang,* Tan Yang,*Wendian Zhang,Yao Lu,Peng Ye,Guang Yang,Bin Li,Shibo Qi,Yong Liu,Xingxing He,Robert J Lee,Chuanrui Xu*,Guangya Xiang*,A novel hydrolysis-resistant lipophilic folate derivative enables stable delivery of targeted liposomes in vivo,International Journal of Nanomedicine ,2014:9 4581–4595(IF=4.195)

◆  Guang Yang, Tan Yang, Wendian Zhang, Miao Lu Xiang Ma,*, and Guangya Xiang*,In Vitro and in Vivo Antitumor Effects of Folate-Targeted Ursolic Acid Stealth Liposome,J. Agric. Food Chem. 2014,62:2207-2215(IF=3.107)

◆  Peng Ye,Wendian Zhang,Tan Yang,Yao Lu,Miao Lu,Yongkang Gai,Xiang Ma*,Guangya Xiang*,Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting, International Journal of Nanomedicine,2014,9:2167-2178(IF=4.195)

◆  Bin Zhao, Xianmei Shang*, Ling Xu, Wendian Zhang, Guangya Xiang*,Novel mixed ligand di-n-butyltin(IV) complexes derived from acylpyrazolones and fluorinated benzoic acids: Synthesis, characterization, cytotoxicity and the induction of apoptosis in Hela cancer cells,European Journal of Medicinal Chemistry,2014,76:87-97(IF=3.432)

◆  Zhi-Gang Cheng,Xu-Yong Dai, Li-Wei Li, Qiong Wan, Xiang Ma,* and Guang-Ya Xiang*,Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance,Molecules2014,19:1344-1352(IF=2.095)

◆  Miao Lu, Wendian Zhang, Yongkang Gai, Tan Yang, Peng Ye, Guang Yang, Xiang Ma* and Guangya Xiang,Folate–PEG functionalized silica CdTe quantum dots as fluorescent probes for cancer cell imaging, New Journal of Chemistry, 2014,38:4519-4526(IF=3.159)

◆  Tan Yang, Bin Li, Shibo Qi, Yong Liu, Yongkang Gai, Peng Ye, Guang Yang, Wendian Zhang, Peng Zhang, Xingxing He, Weijie Li, Zhiping Zhang, Guangya Xiang*, Chuanrui Xu*, Co-delivery of Doxorubicin and Bmi1 siRNA by Folate Receptor Targeted Liposomes Exhibits Enhanced Anti-Tumor Effects in vitro and in vivo, Theranostics, 2014,4(11):1096-1111(IF=7.827)

◆  Chang Yang, Lun Ma, Jason Maley, Ramaswami Sammynaiken,Renfei Feng, Guangya Xiang∗, and Wei Chen∗,Photoluminescence and X-Ray Excited Luminescence from Glutathione-Stabilized Gold Nanoparticles,Journal of Biomedical Nanotechnology,2013,9:1827–1836(IF=7.578)

◆  Changqin Xiao, Minqiong Tang, Jian Li, Chen-ru Yin, Guangya Xiang∗, Li Xu∗,Determination of sildenafil, vardenafil and aildenafil in human plasma by dispersive liquid–liquid microextraction-back extraction based on ionic liquid and high performance liquid chromatography-ultraviolet detection,Journal of Chromatography B,2013,931:111-116(IF=2.694)

◆ Chang Yang,Lun Ma,Xiaoju Zou,Guangya Xiang∗,Wei Chen∗,Surface plasmon-enhanced Ag/CuS nanocomposites for cancer treatment,Cancer Nano, 2013,4:81-89

◆  Xianmei Shang*, Nan Ding, Guangya Xiang*,Novel di-n-butyltin(IV) derivatives: Synthesis, high levels of cytotoxicity in tumor cells and the induction of apoptosis in KB cancer cells,European Journal of Medicinal Chemistry,2012,48:305-312(IF=3.432)

◆  Yao Lu, Nan Ding, Chang Yang, Lei Huang, Jian Liu, and Guangya Xiang∗,Preparation and in vitro evaluation of a folate-linked liposomal curcumin formulation,Journal of Liposome Research, 2012,22(2):110-119(IF=1.533)

◆  Ye, L; Huang, YF; Li; Xiang, GY; Xu, L∗,Nonaqueous capillary electrophoresis of imatinib mesylate and related substances,JOURNAL OF SEPARATION SCIENCE  2012,35(16):2108-2113(IF=2.594)

◆  Jian Li, Yifei Huang, Lei Huang, Lei Ye, Zhou Zhou, Guangya Xiang∗, Li Xu∗, Determination of imatinib mesylate and compounds by field amplified sample stacking with large volume sample injection capillary electrophoresis, Journal of Pharmaceutical and Biomedical Analysis, 2012,70:26-31(IF=2.829)

◆  Chang Yang, Wei Chen, Brian Quang Bui, and Guangya Xiang∗,Recent Progress on the Liposomes Loaded with Quantum Dots, Rev. Nanosci. Nanotechnol, 2012, 1(4):1-14

◆  Nan Ding,Yao Lu, Robert J Lee, Chang Yang, Lei Huang, Jian Liu, Guangya Xiang∗,Folate receptor targeted fluorescentparamagnetic bimodal liposomes for tumor imaging,International Journal of Nanomedicine,2011,6:2513-2520(IF=4.195)

◆  Xiaolan Qu,Chang Yang,Jing Zhang,Nan Ding,Yao Lu,Lei Huang,Guangya Xiang∗,In-vitro evaluation of a folate-bovine serum albumin doxorubicin conjugate,Journal of Drug Targeting, 2010 ,18(5): 351-61. (IF=2.723)

◆  Chang Yang, Nan Ding, Yibing Xu, Xiaolan Qu, Jing Zhang1, Chaoyang Zhao, Liang Hong, Yao Lu, Guangya Xiang*, Folate receptor–targeted quantum dot liposomes as fluorescence probes, Journal of Drug Targeting, 2009, 17(7): 502-511(IF=2.723)

◆  Guangya Xiang*,Jun Wu,Yanhui Lu, Zhilan Liu,Robert J Lee,Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes,International Journal of Pharmaceuticals,2008,356:29-36 (IF=3.785)

◆  Qi Zhang, Guang Ya Xiang*, Youjiu Zhang, et al. Increase of Doxorubicin Sensitivity for Folate Receptor Positive Cells when given as the Prodrug N-(phenylacetyl) doxorubicin in Combination with Folate-conjugated PGA,Journal of Pharmaceutical Sciences,2006, 2006, 95(10):2266-75. (IF=3.007)

Courses Taught

     Organic Chemistry

     Bioconjugate Techniques

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