Professor

Phone: (027)83692733

Email: gyap@mail.hust.edu.cn

Academic Areas: Medicinal Chemistry

Research Interests: Natural Medicinal Chemistry and New Drug Discovery

Academic Degrees

PhD in Medicinal Chemistry, 2005, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China.

MS Organic Chemistry, 2002, Nankai University, China

BA Chemistry, 1999, Qufu Normal University, China.

Professional Experience

Professor (2014-present); School of Pharmacy, Tongji Medical College, HUST, China

Associate Professor (2009-2014); School of Pharmacy, Tongji Medical College, HUST, China

Research Scientist (2008-2009); Hawaii Pacific University, USA

Postdoctoral Associate (2007-2008); Hawaii Pacific University, USA

Postdoctoral Associate (2006-2007); University of Minnesota Duluth, USA

Research Scientist (2005-2006); Shijiazhuang Pharmaceutical Group, China

Selected Publications

(1) Guanqun Zhan, Junjun Liu, Junfei Zhou, Bin Sun, Haji Akber Aisa, Guangmin Yao(*). Amaryllidaceae alkaloids with new framework types from Zephyranthes candida as potent acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry 2016, DIO: 10.1016/j.ejmech.2016.10.057.

(2) Guanqun Zhan, Junfei Zhou, Tingting Liu, Guijuan Zheng, Haji Akber Aisa, Guangmin Yao. Flavans with potential anti-inflammatory activities from Zephyranthes candida. Bioorganic & Medicinal Chemistry Letters 2016, 26, 967–5970.

(3) Guanqun Zhan, Junfei Zhou, Rong Liu, Tingting Liu, Guoli Guo, Jianping Wang, Ming Xiang, Yongbo Xue, Zengwei Luo, Yonghui Zhang, Guangmin Yao(*). Galanthamine, plicamine, and secoplicamine alkaloids from Zephyranthes candida and their anti-acetylcholinesterase and anti-inflammatory activities. Journal of Natural Products 2016, 79 (4), 760–766.

(4) Guanqun Zhan (#), Xiaolan Qu (#), Junjun Liu, Qingyi Tong, Junfei Zhou, Bing Sun, Guangmin Yao(*). Zephycandidine A, the first naturally occurring imidazo[1,2-f]phenanthridine alkaloid from Zephyranthes candida, exhibits significant anti-tumor and anti-acetylcholinesterase activities. Scientific Reports 2016, 6, 33990.

(5) Qi Ye (#), Jue Jiang (#), Guanqun Zhan(#), Wanyao Yan, Liang Huang, Yufeng Hu, Hexiu Su, Qingyi Tong, Ming Yue, Hua Li, Guangmin Yao(*), Yonghui Zhang(*), Hudan Liu(*). Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia. Scientific Reports 2016, 6, 26510.

(6) Yongji Lai, Hong Zeng, Meijun He, Huiqin Qian, Zhaodi Wu, Zengwei Luo, Yongbo Xue, Guangmin Yao(*), Yonghui Zhang(*). 6,8-Di-C-methyl-flavonoids with neuroprotective activities from Rhododendron fortune. Fitoterapia 2016, 112, 237–243.

(7) Yongji Lai, Tingting Liu, Rongjian Sa, Xialan Wei, Yongbo Xue, Zhaodi Wu, Zengwei Luo, Ming Xiang, Yonghui Zhang(*), Guangmin Yao(*). Neolignans with a rare 2-oxaspiro[4.5]deca-6,9-dien-8-one motif from the stem bark of Cinnamomum subavenium. Journal of Natural Products 2015, 78 (7), 1740–1744.

(8) Mengke Zhang, Yangyang Xie, Guanqun Zhan, Liang Lei, Penghua Shu, Yongli Chen, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao(*), Yonghui Zhang(*). Grayanane and leucothane diterpenoids from the leaves of Rhododendron micranthum. Phytochemistry 2015, 117, 107–115.

(9) Qi Ye (#), Guangmin Yao(#), Mengke Zhang, Guoli Guo, Yufeng Hu, Jue Jiang, Ling Cheng, Hua Li, Guoliang Qing, Yonghui Zhang(*), Hudan Liu(*). A novel ent-kaurane diterpenoid executes anti-tumor function in colorectal cancer cells by inhibiting Wnt/b-catenin signaling. Carcinogenesis 2015, 36 (3), 318–326.

(10) Guoli Guo(#), Guangmin Yao(#),Guanqun Zhan, Qi Ye, Jue Jiang, Yufeng Hu, Guoliang Qing, Yonghui Zhang(*), Hudan Liu(*). N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation. Toxicology and Applied Pharmacology 2014, 280 (3), 475–483.

(11) Junfen Zeng, Yongbo Xue, Penghua Shu, Huiqin Qian, Rongjian Sa, Ming Xiang, Xiao-Nian Li, Zengwei Luo, Guangmin Yao(*), Yonghui Zhang(*). Diterpenoids with immunosuppressive activities from Cinnamomum cassia. Journal of Natural Products 2014, 77 (8), 1948–1954.

(12) Mengke Zhang, Yan Zhu, Guanqun Zhan, Penghua Shu, Rongjian Sa, Liang Lei, Ming Xiang, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao(*), Yonghui Zhang(*). Micrantone A, a new diterpenoid with an unprecedented carbon skeleton from Rhododendron micranthum. Organic Letters 2013, 15 (12), 3094–3097.

(13) Heng Zheng, Qiong Chen, Mengke Zhang, Yongji Lai, Liang Lei, Penghua Shu, Yongbo Xue, Zengwei Luo, Jinwen Zhang, Yan Li, Guangmin Yao(*), Yonghui Zhang(*). Cytotoxic ent-kaurane diterpenoids from Salvia cavaleriei. Journal of Natural Products 2013, 76 (12), 2253–2262.

(14) Penghua Shu, Xialan Wei, Yongbo Xue, Weijie Li, Jinwen Zhang, Ming Xiang, Mengke Zhang, Zengwei Luo, Yan Li, Guangmin Yao(*), Yonghui Zhang(*). Wilsonols AL, megastigmane sesquiterpenoids from the leaves of Cinnamomum wilsonii. Journal of Natural Products 2013, 76 (7), 1303–1312..

(15) Yongji Lai(#), Yongbo Xue(#), Mengke Zhang, Jinwen Zhang, Wei Tang, Junjun Liu, Liang Lei, Juming Yan, Zengwei Luo, Jianping Zuo, Yan Li, Guangmin Yao(*), Yonghui Zhang(*). Scapiformolactones A–I: germacrane sesquiterpenoids with an unusual Δ3-15,6-lactone moiety from the whole plants of Salvia scapiformis. Phytochemistry 2013, 96, 378–388..

(16) Xincai Hao(#), Jinwen Zhang(#), Guangxin Xia, Yongbo Xue, Zengwei Luo, Yanyan Si, Guangmin Yao(*), Yonghui Zhang(*). A new triterpenoid from Teucrium viscidum. Molecules 2013, 18 (1), 1262–1269.

(17) Yongji Lai(#), Shuiping Ding(#), Huiqin Qian, Jinwen Zhang, Yongbo Xue, Zengwei Luo, Guangmin Yao(*), Yonghui Zhang(*). A new lignan glucoside from the whole plants of Salvia scapiformis. Molecules 2013, 18 (9), 11377–11383.

(18) Xincai Hao(#), Jinwen Zhang(#), Guanqun Zhan, Yongbo Xue, Zengwei Luo, Guangmin Yao(*), Yonghui Zhang(*). Chemical constituents from Teucrium viscidum. Biochemical Systematics and Ecology 2013, 51, 78–82.

(19) Xialan Wei, Penghua Shu, Tingting Liu, Ming Xiang, Jinwen Zhang, Yongbo Xue, Zengwei Luo, Guangmin Yao(*), Yonghui Zhang(*). Steroids and Phenylpropanoids with Immunomodulatory Activities from the Stem Barks of Cinnamomum wilsonii. Chinese Journal of Organic Chemistry. 2013, 33 (6), 1273–1278.

(20) Hong Zeng, Huiqin Qian, Zhaochang Liang, Yajun Yang, Hongbiao Chu, Guangmin Yao(*), Yonghui Zhang(*). Studies on the chemical constituents of the branches and leaves of Rhododendron fortune. Chinese Herb Medicine,,2013, 44 (22), 3123–3126.

(21) Zengwei Luo, Fuqian Wang, Jinwen Zhang, Xingyao Li, Mengke Zhang, Xincai Hao, Yongbo Xue, Yan Li, F. David Horgen, Guangmin Yao(*), Yonghui Zhang(*). Cytotoxic alkaloids from the whole plants of Zephyranthes candida. Journal of Natural Products 2012, 75 (12), 2113–2120.

(22) Jieru Guo, Jinwen Zhang, Penghua Shu, Lingmei Kong, Hao, Xincai; Xue, Yongbo; Zengwei Luo, Gao Li, Yan Li, Guangmin Yao(*), Yonghui Zhang(*). Two new diterpenoids from the buds of Wikstroemia chamaedaphne. Molecules 2012, 17 (6), 6424–6433.

(23) Guangmin Yao, Fred Musoke Sebisubi, Lok Yung Christopher Voo, Coy Choke Ho, Ghee Teng Tan, Leng Chee Chang(*). Citrinin derivatives from the soil filamentous fungus Penicillium sp. H9318. Journal of the Brazilian Chemical Society 2011, 22 (6), 1125–1129.

(24) Susanna Zierler, Guangmin Yao, Zheng Zhang, Cedric W. Kuo, Peter Poerzgen, Reinhold Penner, F. David Horgen, Andrea Fleig(*). Waixenicin A inhibits cell proliferation through magnesium-dependent block of TRPM7. Journal of Biological Chemistry 2011, 286 (45), 39328–39335.

Courses Taught

1002271: Natural Medicinal Chemistry (undergraduate)

1002132: Spectroscopic Analysis (undergraduate)

514.505: Spectroscopic Analysis (graduate)

514.507: Research Methods in Natural Medicinal Chemistry (graduate)

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