Professor

Phone: (027) 83692892

Email: zhangyh@mails.tjmu.edu.cn

Academic Areas: Bioactive Natural Medicines and Innovative Drugs

Research Interests: Bioactive Natural Products from Medicinal Plants and Various Fungi, such as PPAPs, Cytochalasans, and Meroterpenoids

Academic Degrees

Ph D in School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Master of Pharmacy, School of Pharmacy, Tongji Medical College, Wuhan, China

Bachelor of Pharmacy, School of Pharmacy, Tongji Medical College, Wuhan, China

Professional Experience

Professor (2008-present): School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology

Associate Professor (2005-2008): School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology

Lecturer (2002-2005): School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology

Selected Publications

1.Ying Tang(#), Yongbo Xue(#), Guang Du(#), Jianping Wang, Junjun Liu, Bin Sun, Xiao-Nian Li, Guangmin Yao, Zengwei Luo, Yonghui Zhang(*), Structural Revisions of a Class of Natural Products: Scaffolds of Aglycon Analogues of Fusicoccins and Cotylenins Isolated from Fungi, Angewandte Chemie International Edition, 2016, 55: 4069-4073. (IF = 11.709)

2.Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong, Xiao-Nian Li, Jing Yang, Yongbo Xue, Zengwei Luo, Jianping Wang, Guangmin Yao, Yonghui Zhang(*), Epicochalasines A and B: Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes, Angewandte Chemie International Edition, 2016, 55: 3486-3490. (IF = 11.709)

3.Hucheng Zhu(#), Chunmei Chen(#), Yongbo Xue(#), Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao, Zengwei Luo, Yonghui Zhang(*), Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, from Aspergillus flavipes, Angewandte Chemie International Edition, 2015, 54: 13374-13378. (IF = 11.709)

4.Changxing Qi(#), Jian Bao(#), Jianping Wang(#), Hucheng Zhu, Yongbo Xue, Xiaochuan Wang, Hua Li, Weiguang Sun, Weixi Gao, Yongji Lai, Jian-Guo Chen, and Yonghui Zhang(*), Asperterpenes A and B, Two Unprecedented Meroterpenoids from Aspergillus terreus with BACE1 Inhibitory Activities, Chemical Science, 2016, 7, 6563-6572. (IF = 9.144)

5.Ming Xiang(#), Tingting Liu(#), Wanyue Tan, Hongyu Ren, Hua Li, Junjun Liu, Hui Cao, Qi Cheng, Xiulan Liu, Hucheng Zhu, Yali Tuo, Jianping Wang, and Yonghui Zhang(*), Effects of kinsenoside, a potential immunosuppressive drug for autoimmune hepatitis, on DCs-CD8+T cells communication, Hepatology, 2016, 64, 2135-2150. (IF = 11.711)

6.Linzhen Hu(#), Yu Zhang(#), Hucheng Zhu, Junjun Liu, Hua Li, Xiao-Nian Li, Weiguang Sun, Junfen Zeng, Yongbo Xue, Yonghui Zhang(*), Filicinic Acid-based Meroterpenoids with Anti-Epstein-Barr virus Activities from Hypericum japonicum, Organic Letters, 2016, 18, 2272-2275. (IF = 6.732)

7.Zheng-Xi Hu(#), Yi-Ming Shi(#), Wei-Guang Wang, Jian-Wei Tang, Min Zhou, Xue Du, Yong-Hui Zhang(*), Jian-Xin Pu(*), and Han-Dong Sun, Structural Characterization of Kadcoccinin A: A Sesquiterpenoid with a Tricyclo[4.4.0.03,10]decane Scaffold from Kadsura coccinea, Organic Letters, 2016, 18, 2284-2287. (IF = 6.732)

8.Zheng-Xi Hu(#), Yi-Ming Shi(#), Wei-Guang Wang, Xiao-Nian Li, Xue Du, Miao Liu, Yan Li, Yong-Bo Xue, Yong-Hui Zhang(*), Jian-Xin Pu(*), Han-Dong Sun, Kadcoccinones A-F, New Biogenetically Related Lanostane-Type Triterpenoids with Diverse Skeletons from Kadsura coccinea, Organic Letters, 2015, 17(18): 4616-4619. (IF = 6.732)

9.Ming Yuan, Li Chen, Junwei Wang, Shenjie Chen, Kongchao Wang, Yongbo Xue, Guangmin Yao, Zengwei Luo(*), Yonghui Zhang(*), Transition-Metal-Free Synthesis of Phenanthridinones from Biaryl-2-oxamic Acid under Radical Conditions, Organic Letters, 2015, 17(2): 346-349. (IF = 6.732)

10.Chunmei Chen(#), Hucheng Zhu(#), Xiao-Nian Li, Jing Yang, JianpingWang, Gentao Li, Yan Li, Qingyi Tong, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*), Armochaeglobines A and B, Two New Indole-Based Alkaloids from the Arthropod-Derived Fungus Chaetomium globosum, Organic Letters, 2015, 17(3): 644-647. (IF = 6.732)

11/Hucheng Zhu, Chunmei Chen, Jing Yang, Xiao-Nian Li, Junjun Liu, Bin Sun, Sheng-Xiong Huang, Dongyan Li, Guangmin Yao, Zengwei Luo, Yan Li, Jinwen Zhang, Yongbo Xue(*), Yonghui Zhang(*), Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii, Organic Letters, 2014, 16(24): 6322-6325. (IF = 6.732)

12.Mengke Zhang, Yan Zhu, Guanqun Zhan, Penghua Shu, Rongjian Sa, Liang Lei, Ming Xiang, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao(*), Yonghui Zhang(*), Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeleton from Rhododendron micranthum, Organic Letters, 2013, 15(12): 3094-3097. (IF = 6.732)

13.Zheng-Xi Hu, Kun Hu, Yi-Ming Shi, Wei-Guang Wang, Xue Du, Yan Li, Yong-Hui Zhang(*), Jian-Xin Pu(*), and Han-Dong Sun, Rearranged 6/6/5/6-Fused Triterpenoid Acids from the Stems of Kadsura coccinea, J. Nat. Prod. 2016, 79, 2590–2598. (IF = 3.662)

14.Linzhen Hu, Yongbo Xue, Jinwen Zhang, Hucheng Zhu, Chunmei Chen, Xiao−Nian Li, Junjun Liu, Zhenzhen Wang, Yu Zhang(*), Yonghui Zhang(*), (±)-Japonicols A–D, Acylphloroglucinol-based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum, Journal of Natural Products, 2016, 79, 1322-1328. (IF = 3.662)

15.Yuanyuan Lu(#), Yongbo Xue(#)(*), Junjun Liu, Guangmin Yao, Dongyan Li, Bin Sun, Jinwen Zhang, Yanfei Liu, Changxing Qi, Ming Xiang, Zengwei Luo, Guang Du(*), Yonghui Zhang(*), (+/-)-Acortatarinowins A-F, Norlignan, Neolignan, and Lignan Enantiomers from Acorus tatarinowii, Journal of Natural Products, 2015, 78(9): 2205-2214. (IF = 3.662)

16.Yongji Lai, Tingting Liu, Rongjian Sa, Xialan Wei, Yongbo Xue, Zhaodi Wu, Zengwei Luo, Ming Xiang, Yonghui Zhang(*), Guangmin Yao(*), Neolignans with a Rare 2-Oxaspiro[4.5]deca-6,9-dien-8-one Motif from the Stem Bark of Cinnamomum subavenium., Journal of Natural Products, 2015, 78(7): 1740-1744. (IF = 3.662)

17.Chunmei Chen, Jianping Wang, Junjun Liu, Hucheng Zhu, Bin Sun, Jing Wang, Jinwen Zhang, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), Yonghui Zhang(*), Armochaetoglobins A-J: Cytochalasan Alkaloids from Chaetomium globosum TW1-1, a Fungus Derived from the Terrestrial Arthropod Armadillidium vulgare, Journal of Natural Products, 2015, 78(6): 1193-1201. (IF = 3.662)

18.Junfen Zeng, Yongbo Xue, Penghua Shu, Huiqin Qian, Rongjian Sa, Ming Xiang, Xiao-Nian Li, Zengwei Luo, Guangmin Yao(*), Yonghui Zhang(*), Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia, Journal of Natural Products, 2014, 77(8): 1948-1954. (IF = 3.662)

19.Heng Zheng, Qiong Chen, Menke Zhang, Yongji Lai, Liang Lei, Penghua Shu, Jinwen Zhang, Yongbo Xue, Zengwei Luo, Yan Li, Guangmin Yao(*), Yonghui Zhang(*), Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei, Journal of Natural Products, 2013, 76(12): 2253-2262. (IF = 3.662)

20.Penghua Shu, Xialan Wei, Yongho Xue, Weijie Li, Jinwen Zhang, Ming Xiang, Mengke Zhang, Zengwei Luo, Yan Li, Guangmin Yao(*), Yonghui Zhang(*), Wilsonols A-L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii, Journal of Natural Products, 2013, 76(7): 1303-1312. (IF = 3.662)

21.Zengwei Luo(#), Fuqian Wang(#), Jinwen Zhang, Xingyao Li, Mengke Zhang, Xincai Hao, Yongbo Xue, Yan Li, F. David Horgen, Guangmin Yao(*), Yonghui Zhang(*), Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida, Journal of Natural Products, 2012, 75(12): 2113-2120. (IF = 3.662)

22.Tao Zheng(#), Xiaoyan Yang(#), Dan Wu, Shasha Xing, Fang Bian, Wenjing Li, Jiangyang Chi, Xiangli Bai, Guangjie Wu, Xiaoqian Chen, Yonghui Zhang(*), Si Jin(*), Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3β pathway, British Journal of Pharmacology, 2015, 17: 3284-3301. (IF = 5.228)

23.Qi Ye(#), Guangmin Yao(#), Mengke Zhang, Guoli Guo, Yufeng Hu, Jue Jiang, Ling Cheng, Jianguo Shi, Hua Li, Yonghui Zhang(*), Liu, Hudan(*), A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/β-catenin signaling, Carcinogenesis, 2015, 36(3): 318-326. (IF = 4.874)

Courses Taught

     Spectrometric Identification

     Natural Medicinal Chemistry

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