Associate Professor

Phone: 027-83692745

Email: jiangenghuang@hust.edu.cn

Academic Areas: Pharmacokinetics

Research Interests: Bile acid transporter and enzyme based mechanism for drug induced liver injury, Drug transport mechanism across blood brain barrier, Nose-to-brain transport of CNS targeting drugs

Academic Degrees

1. PhD in Pharmacology, 2008, Huazhong Univ Sci Tech, Wuhan, China;

2. BS in Pharmacy, 2003, Huazhong Univ Sci Tech, Wuhan, China.

Professional Experience

1. Associate Professor (2012-present); School of Pharmacy, HUST

2. Post-doctoral Research Scholar (2010-2012); University of Iowa, USA

3. Post-doctoral Research Associate (2008-2010); University of Nebraska Medical Center, USA

Selected Publications

1.   Jiaqiang Xu, Gao Li, Zhuoyi Wang, Luqin Si, Sijie He, Jialing Cai, Jiangeng Huang*, Maureen D. Donovan*. The role of L-type amino acid transporters in the uptake of glyphosate across mammalian epithelial tissues. Chemosphere. Feb 1 2016, 145:487-494.

2.  Peng Cao, Gao Li, Ling Huang, Shouwei Zhao, Yang Hu, Lixia Qin, Lihui Qiu, Wenwen Zhu, Luqin Si, Jiangeng Huang*. Screening of stabilizers for LC-MS/MS analysis of clevidipine and its primary metabolite in dog whole blood. Bioanalysis. Jul 1 2015, 12(7):1457-1469.

3.  Lei Hu, Zhenhua Lv, Gao Li, Xiaolong Xu, Chenghao Zhang, Peng Cao, Jiangeng Huang*, Luqin Si*. Study of the in vitro metabolism of TJ0711 using ultra high performance liquid chromatography with quadrupole time-of-flight and ultra fast liquid chromatography with quadrupole linear ion trap mass spectrometry. J Sep Sci. Jun 1 2015, 38(11):1837-1849.

4.  Kewen Xue, Gao Li, Xiao Sun, Yang Hu, Lei Hu, Jiangeng Huang*, Luqin Si*. Simultaneous quantification of fosinopril and its active metabolite fosinoprilat in rat plasma by UFLC-MS/MS: Application of formic acid in the stabilization of an ester-containing drug. J Chromatogr B Analyt Technol Biomed Life Sci. May 15 2015, 990:141-149.

5.  Weilin Guo, Gao Li, Yanxia Yang, Conglian Yang, Luqin Si*, Jiangeng Huang*. LC-MS/MS analysis of pramipexole in mouse plasma and tissues: Elimination of lipid matrix effects using weak cation exchange mode based solid-phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci. Apr 15 2015, 988:157-165.

6.  Gang Zhao, Jiangeng Huang, Kewen Xue, Luqin Si*, Gao Li. Enhanced intestinal absorption of etoposide by self-microemulsifying drug delivery systems: roles of P-glycoprotein and cytochrome P450 3A inhibition. European Journal of Pharmaceutical Sciences. Aug 25 2013, 50:429-439.

7.   Yani Liu, Jiangeng Huang, Jinmei Liu, Lin Ma, Yongning Lv, Shaojun Shi*. A simple and sensitive liquid chromatographic technique for the determination of cefotetan disodium in human plasma and its application in a pharmacokinetic study. J Huazhong Univ Sci Technolog Med Sci. Oct 18 2012, 32(5):779-784.

8.  Hardeep S Oberoi, Natalia V Nukolova, Frederic C Laquer, Larisa Y Poluektova, Jiangeng Huang, Yazen Alnouti, Masanao Yokohira, Lora L Arnold, Alexander V Kabanov, Samuel M Cohen, Tatiana K Bronich*. Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice. Int J Nanomedicine. Jun 8 2012, 7:1-15.

9.  Sai P. Bathena, Jiangeng Huang, Adrian A. Epstein, Howard E. Gendelman, Michael D. Boska, Yazen Alnouti*.  Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. Apr 15 2012, 893-894:15-20.

10.Jiangeng Huang, Lei Hu, Li Xu, Minghui Sun, Zhaoze Fan, Jun Qiu, Gao Li, Luqin Si*.  In vitro enantioselective metabolism of TJ0711 hydrochloride by human liver microsomes using a novel chiral liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. April 1 2012, 891-892:98-101.

11.  Jiangeng Huang, Juanjuan Liu, Cong Zhang, Jiaojiao Wei, Li Mei, Shan Yu, Gao Li*, Li Xu*.  Determination of sulfonamides in food samples by membrane-protected micro-solid phase extraction coupled with high performance liquid chromatography. J Chromatogr A. Jan 6 2012, 1219:66-74.

12. Yanbin Guan, Jiangeng Huang, Lan Zuo, Jiaqiang Xu, Luqin Si, Jun Qiu, Gao Li*.  Effect of pluronic P123 and F127 block copolymer on P-glycoprotein transport and CYP3A metabolism. Arch Pharm Res. Oct 1 2011, 34(10):1719-1728.

13. Jiangeng Huang, Luqin Si, Zhaoze Fan, Lei Hu, Jun Qiu, Gao Li*.  In vitro metabolic stability and metabolite profiling of TJ0711 hydrochloride, a newly developed vasodilatory β-blocker, using a liquid chromatography-tandem mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. Nov 15 2011, 879(30):3386-3392.

14. Jiangeng Huang, Nagsen Gautam, Sai Praneeth R. Bathena, Upal Roy, JoEllyn McMillan, Howard E. Gendelman, Yazen Alnouti*.  UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues. J Chromatogr B Analyt Technol Biomed Life Sci. Aug 1 2011, 879(23):2332-2338.

15. Sai Praneeth R. Bathena, Jiangeng Huang, M.E. Miyamoto, L.C. Parrish, M.S. Lang, T.P. McVaney, M.L. Toews, D.R. Cerutis, Yazen Alnouti*.  Quantitative determination of lysophosphatidic acids (LPAs) in human saliva and gingival crevicular fluid (GCF) by LC-MS/MS. J Pharm Biomed Anal. Sep 10 2011, 56(2):402-407.

16. Jiangeng Huang, Sai Praneeth R. Bathena, Ivan L. Csanaky, Yazen Alnouti*.  Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS. J Pharm Biomed Anal. Jul 15 2011, 55(5):1111-1119.

  1. Lingdong Quan, Fang Yuan, Xinming Liu, Jiangeng Huang, Yazen Alnouti, Dong Wang*. Pharmacokinetic and biodistribution studies of N-(2-hydroxypropyl) methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model. Mol Pharm. Aug 2 2010, 7(4):1041-1049.
  2. Jiangeng Huang, Sai Praneeth R. Bathena, Yazen Alnouti*. Metabolite profiling of Praziquantel and its analogs during the analysis of in vitro metabolic stability using information-dependent acquisition on a hybrid triple-quadrupole linear ion trap mass spectrometer. Drug Metab Pharmacokinet. Sep 22 2010, 25(5):487-499.

19. Yuxiang Dong, Jacques Chollet, Mireille Vargas, Nuha R. Mansour, Quentin Bickle, Yazen Alnouti, Jiangeng Huang, Jennifer Keiser, Jonathan L. Vennerstrom*. Praziquantel analogs with activity against juvenile Schistosoma mansoni. Bioorg Med Chem Lett. Apr 15 2010, 20(8):2481-2484.

20. Jiangeng Huang, Sai P. Bathena, Jing Tong, Megan Roth, Bruno Hagenbuch, Yazen Alnouti*. Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. Mar 1 2010, 40(3):184-194.

21. Ying Chen, Gao Li, Jiangeng Huang, Ruihua Wang, Hong Liu, Ren Tang. Comparison of self-microemulsifying drug delivery system versus solid dispersion technology used in the improvement of dissolution rate and bioavailability of vinpocetine. Yao Xue Xue Bao. Jun 1 2009, 44(6):658-666.

22.  Luqin Si, Ying Zhao, Jiangeng Huang, Sha Li, Xuezhen Zhai, Gao Li. Calcium pectinate gel bead intended for oral protein delivery: preparation improvement and formulation development. Chem Pharm Bull. Jul 1 2009, 57(7):663-667.

23.  Luqin Si, Gao Li, Sanlan Wu, Jiangeng Huang, Dapeng Wu, Quan Gan. Disposition and tissue distribution of ML12 in rats. J Huazhong Univ Sci Technolog Med Sci.Apr 1 2008, 28(2):125-127.

24.  Jiangeng Huang, Luqin Si, Lingli Jiang, Zhaoze Fan, Jun Qiu, Gao Li. Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism. Int J Pharm. May 22 2008, 356(1-2):351-353.

25.  Ying Chen, Gao Li, Xianggen Wu, Zhiyu Chen, Jiangeng Huang, Bei Qin, Song Chen, Ruihua Wang. Self-microemulsifying drug delivery system (SMEDDS) of vinpocetine: formulation development and in vivo assessment. Biol Pharm Bull. Jan 1 2008, 31(1):118-125.

Courses Taught

1. Drug transport and metabolism;

2. Clinical Pharmacokinetics;

3. Biopharmaceutics & Pharmacokinetics;

4. Basic Pharmacokinetics.

Project

· 1. OCT1/OCT3 medatied transport mechanism of anti-Parkinson drugs across nasal mucosa (Fundamental Research Funds for the Central Universities, HUST 2016YXMS141, 2016-2019).

· 2. Study on mechanism of tolvaptan induced liver injury based on NTCP/Ntcp and BSEP/Bsep mediated bile acid transport obstruction (NSFC 81302837, 2014-2016).

· 3. Diagnosis of drug induced liver injury based on bile acid metabolism (Hubei Natural Science Funds 2014CFB956, 2014-2015).

· 4. Transfected cell models to investigate the mechanism for tolvaptan induced liver injury (Fundamental Research Funds for the Central Universities, HUST 2014QN135, 2014-2015)

· 5. Transport mechanism of anti-depression drugs across blood-brain-barrier (Key Fundamental Research Funds for the Central Universities, HUST 2013QT007, 2013-2014)

· 6. Nose-to-brain transport mechanism of pramipexole after intranasal administration (Ministry of Health of Hubei Province QJX2012-02, 2013-2014)

· 7. Brain targeting of anti-Parkinson drugs after intranasal administration (Fundamental Research Funds for the Central Universities, HUST 2012QN014, 2012-2013)

· 8. Intranasal delivery system for anti- Parkinson drugs (HUST Starting Funds, 2012-2015)

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