Associate Professor

Phone: 027-83692745

Email: 183446033@qq.com

Academic Areas: Biocatalytic synthesis of carbohydrates and glycoconjugates

Research Interests: Focus on the enzyme/cell-mediated synthesis of functional oligosaccharides, glycosylation of natural products, and development of carbohydrate-based anti-infective or cancer-targeted drugs.

Academic Degrees

1.Ph.D. Microbiology in State Key Lab of Microbial Technology, Shandong University, Jinan, China, 2007;

2.B.S. Biology in School of Biology, Hubei Nomal University, Huangshi, China, 2002

Professional Experience

1. Associate Professor (2016.12- present): School of Pharmaceutical Science, Tongji Medical College, HUST, China;

2. Associate Professor (2010.12-2016.11): National Glycoengineering Research Center, Shandong University, China;

3. Visiting Scholar (2013.7-2014.9): Chemistry of Wayne State University, USA;

4. Postdoctor (2007.10-2009.12): School of Pharmaceutical Science, Shandong University, China;

5. Lecturer (2007.7-2010.11): National Glycoengineering Research Center, Shandong University, China.

Selected Publications

  1. 1.Xiaodi Chen, Li Xu, Lan Jin, Bin Sun, Guofeng Gu, Lili Lu*, Min Xiao*. Efficient and regioselective synthesis of β-GalNAc/GlcNAc-lactose by a bifunctional transglycosylating β-N-acetylhexosaminidase from Bifidobacterium bifidum. Appl Environ Microbiol. 2016, 82(18):5642-5652.
  2. 2.Wei Gong, Li Xu, Guofeng Gu, Lili Lu*, Min Xiao*. Efficient and regioselective synthesis of globotriose by a novel α-galactosidase from Bacteroides fragilis. Appl Microbiol Biotechnol. 2016, 100(15):6693-6702.
  3. 3.Lijuan Xu, Tingting Qi, Li Xu, Lili Lu*, Min Xiao*. Recent progress in the enzymatic glycosylation of phenolic compounds. J Carbohyd Chem. 2016, 35(1):1-23.
  4. 4.Jie Zhang #, Lili Lu #, Li Lu, Yang Zhao, Liping Kang, Xu Pang, Jingyuan Liu, Tengchuan Jiang, Min Xiao*, Baiping Ma*. Galactosylation of steroidal saponins by β-galactosidase from Lactobacillus bulgaricus L3. Glycoconj J. 2016, 33(1):53-62.
  5. 5.Lili Lu#, Jian Gao#, Zhongwu Guo*. Labeling cell surface GPIs and GPI-anchored proteins through metabolic engineering with artificial inositol derivatives. Angew Chem Int Ed. 2015, 54(33): 9679-9682.
  6. 6.Lili Lu#, Qian Liu#, Lan Jan, Zhenghao Yin, Li Xu, Min Xiao*. Enzymatic synthesis of rhamnose containing chemicals by reverse hydrolysis. PLoS One. 2015, 10(10):e0140531.
  7. 7.Lili Lu, Lijuan Xu, Yuchuan Guo, Dayu Zhang, Tingting Qi, Lan Jin, Guofeng Gu, Li Xu, and Min Xiao*. Glycosylation of phenolic compounds by the site-mutated β-galactosidase from Lactobacillus bulgaricus L3. PLoS One. 2015, 10(3):e0121445.
  8. 8.Lili Zhang#, Lili Lu# Shuquan Fan#, Lan Jin, Guofeng Gu, Li Xu, and Min Xiao*. One-step synthesis of α-Gal epitope and globotriose derivatives by an engineered α-galactosidase, RSC Adv. 2015, 5, 22361-22364.
  9. 9.Lili Lu, Feng Fu, Renfei Zhao, Lan Jin, Chunjuan He, Min Xiao*. A recombinant levansucrase from Bacillus licheniformis 8-37-0-1 catalyzes versatile transfructosylation reactions. Process Biochem. 2014, 49: 1503-1510.
  10. 10.Lili Lu, Jian Wu, Deyong Song, Han Zhao, Yuchuan Guo, Guofeng Gu, Nan Jin, Min Xiao*. Purification of fructooligosaccharides by immobilized yeast cells and identification of a novel glycoside formed during the process. Bioresour Technol. 2013, 132: 365-369.
  11. 11.Lili Lu, Shuze Xu, Renfei Zhao, Dayu Zhang, Zhengyi Li, Yumei Li, Min Xiao*. Synthesis of galactooligosaccharides by CBD fusion β-galactosidase immobilized on cellulose. Bioresource Technol. 2012, 116:327-33.
  12. 12.Lili Lu, Shuze Xu, Lan Jin, Dayu Zhang, Yumei Li, Min Xiao*. Synthesis of galactosyl sucralose by β-galactosidase from Lactobacillus bulgaricus L3. Food Chem. 2012, 134(1): 269-275.
  13. 13.Qian Liu#, Lili Lu#, Min Xiao*. Cell surface engineering of α-L-rhamnosidase for naringin hydrolysis. Bioresource Technol. 2012, 123: 144–149.
  14. 14.Lili Lu#, Guofeng Gu#, Min Xiao*, Fengshan Wang. Separation and structure analysis of trisaccharide isomers produced from lactose by Lactobacillus bulgaricus L3 β-galactosidase. Food Chem. 2010, 121(4):1283-1288.
  15. 15.Lili Lu, Xiaodong Xu, Min Xiao*, Fengshan Wang. Synthesis of novel galactose-containing chemicals by β-galactosidase from Enterobacter cloacae B5. Bioresource Technol. 2010, 101(17): 6868-6872.
  16. 16.Yumei Li#, Lili Lu#, Hongmei Wang, Xiaodong Xu, Min Xiao*. Cell-surface engineering of a β-galactosidase for galactooligosaccharide synthesis. Appl Environ Microbiol. 2009, 75(18): 5938-5942.
  17. 17.Lili Lu, Min xiao*, Zhengyi Li, Yumei Li, Fengshan wang. A novel transglycosylating β-galactosidase from Enterobacter cloacae B5. Process Biochem. 2009, 44 (2): 232-236.
  18. 18.Lili Lu, Min Xiao*, Han Zhao, Xiaodong Xu, Fengshan Wang. Pharmacological chaperones: novel therapeutic strategies to rescue defective protein folding and trafficking. Prog Biochem Biophys. 2008, 35(8): 875-885.
  19. 19.Lili Lu, Min Xiao*, Xiaodong Xu, Zhengyi Li, Yumei Li. A novel β-galactosidase capable of glycosyl transfer from Enterobacter agglomerans B1. Biochem Biophys Res Commun. 2007, 356 (1): 78-84.
  20. 20.Lili Lu, Min Xiao*, Han Zhao, Peng Wang, Xinmin Qian. 1-Glycosyl fluorides in carbohydrate synthesis by chemoenzymatic methods. Chinese J Org chem. 2006, 26 (12): 1631-1639.
  21. 21.Lili Lu, Min Xiao*, Han Zhao, Peng Wang, Xinmin Qian. Glycosynthases: a novel efficient synthetic tool for oligosaccharides. Prog Biochem Biophys. 2006, 33 (4): 310-320.

Awards and Honors

  1. Lili Lu, Min Xiao, Yuchuan Guo. A method for preparation of catechol galactoside. Patent number: ZL 2013 1 0255797.5, 08/05/2015
  2. Lili Lu, Min Xiao, Yuchuan Guo. Caffeic acid glycosides and their preparation. Patent number: ZL 2013 1 0257383.6, 06/10/2015  
  3. Lili Lu, Min Xiao, Yuchuan Guo. m-Trihydroxybenzene glycosides and their preparation. Patent number: ZL 2013 1 0256401.9, 09/17/2014
  4. Lili Lu, Min Xiao, Yuchuan Guo. A method for preparation of resveratrol galactoside. Patent number: ZL 2013 1 0257340.8, 08/27/2014

Courses Taught

Microbial Detection Technology, Microbe and Human, Glycobiology

Project

  1. 2015-2017 Glycosidase-mediated synthesis of anti-infective oligosaccharide drugs against enterohemorrhagic Escherichia coli. Key Development Project of Shandong Province (2015GSF121004).
  2. 2012-2015 Large scale production of burdock fructooligosaccharide and development of galactosidases. Sub-project of National High Technology Research and Development Program (863) of China (2012AA021501).
  3. 2012-2014 Synthesis of globotriose by α-galactosidase. Independent Innovation Foundation of Shandong University (2012TS014).
  4. 2011-2013 Broadening acceptor selectivity for transglycosylation by molecular modification of β-galactosidase. National Natural Science Foundation of China (31000035).
  5. 2011-2012 Glycosylation of phenolic chemicals by β-galactosidases. Science and Technology Development Project of Shandong Province (2011GSF12104).
  6. 2009-2011 Molecular evolution of glycosidase to broaden the acceptor selectivity for transglycosylation. Research Fund for the Doctoral Program of Higher Education of China (200804221016).
  7. 2008-2009 Widening the acceptor selectivity for transglycosylation by glycosidase engineering. China Postdoctoral Science Foundation (20080431187).
  8. 2008-2009 Structure and bioactivity of galactooligosaccharide produced by probiotics. Special Funds for Postdoctoral Innovative Projects of Shandong Province (200802025).
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