Professor

Phone: 027-83692745

Email: ruanhl@mail.hust.edu.cn; ruanhl@hust.edu.cn

Academic Areas: Medicinal Chemistry, Pharmaceutical biology

Research Interests: Chemistry, Bioactivity, and biosynthesis of Natural Products; Drug Discovery

Academic Degrees

Ph.D. in pharmacology, 2004, Huazhong University of Science and Technology (HUST), Wuhan, China

M.S. in Medicinal Chemistry, 1999, Tongji Medical University, Wuhan, China

B.S. in Chinese Materia Medica, 1989, China Pharmaceutical University, Nanjing, China

Professional Experience

Professor (2009-present); School of Pharmacy, Tongji Medical College, HUST

Associate Professor (2002-2009); School of Pharmacy, Tongji Medical College, HUST

Lecture (1997-2002); School of Pharmacy, Tongji Medical College, HUST

Associate Professor (1992-1997); School of Pharmacy, Tongji Medical College, HUST

Senior Visiting Scholar (2014.01-2014.06); University of Marburg, Germany

Visiting Scholar (2008.07-2008.10, 2007.07-2007.10, 2006.03-2006.09); University of Duesseldorf, Germany

Visiting Scholar (2005.09-2006.03); University of Tuebingen, Germany

Selected Publications

*  Ye Liu, Yan-Mei Wang, Wen-Ming Wu, Jian Song, Han-Li Ruan*. Triterpenoids and lignans from the fruit of Schisandra sphenanthera. Fitoterapia, 2017, 116:10–16

*  Ming Zhou, Ye Liu, Jian Song, Xiao-Gang Peng, Qi Cheng, Hui Cao, Ming Xiang, and Han-Li Ruan*, Schincalide A, a Schinortriterpenoid with a Tricyclo[5.2.1.01,6]decane-Bridged System from the Stems and Leaves of Schisandra incarnate. Organic Letters, 2016, 18 (18), 4558–4561

*  Wen-Ming Wu, Xu Chen, Ye Liu, Yan-Mei Wang, Tian Tian, Xiao-Ya Zhao, Juan Li, Han-Li Ruan*. Triterpenoids from the branch and leaf of Abies fargesii. Phytochemistry, 2016, 130, 301–312

*  Heng-Yi Yu, Juan Li, Ye Liu, Wen-Ming Wu, Han-Li Ruan*. Triterpenoids from the fruit of Schisandra glaucescens. Fitoterapia, 2016, 113, 64–68.

*  Wen-Ming Wu, Ye Liu, Xu Chen, An Jin, Ming Zhou, Tian Tian, Han-Li Ruan*, Diterpenoids from the branch and leaf of Abies fargesii, Fitoterapia, 2016, 110: 123-128.

*  Tian Tian, Ye Liu, Heng-Yi Yu, Yun-Yun Zhu, Xiao-Ya Zhao, Han-Li Ruan* Dibenzocyclooctadiene Lignans from the Fruits of Schisandra viridis, Chemistry of Natural Compounds, 2015, 51 (6):1046-1048

*  An Jin, Wen-Ming Wu, Heng-Yi Yu, Ming Zhou, Ye Liu, Tian Tian, and Han-Li Ruan* Bisabolane-Type Sesquiterpenoids from the Whole Plant of Parasenecio rubescens, Journal of Natural Products, 2015, 78 (8): 2057–2066

*  Yun-Yun Zhu, Xue Li, Heng-Yi Yu, Yu-Fang Xiong, Peng Zhang, Hui-Fang Pi, Han-Li Ruan* Alkaloids from the bulbs of Lycoris longituba and their neuroprotective and acetylcholinesterase inhibitory activities Archives of Pharmacal Research, 2015, 38 (5): 604-613

*  Yuan Gan, Yang Zhang, Aiqian Li, Chengwu Song, Chang Chen, Yong Xu, Hanli Ruan*, Hongliang*. Jiang, A Novel Four-step Approach for Systematic Identification of Naphthoquinones in Juglans cathayensis Dode using Various Scan Functions of Liquid Chromatography-Tandem Mass Spectrometry along with Data Mining Strategies. Phytochemical Analysis, 2015, 26(6): 413–422

*  Heng-Yi Yu, Zu-Yu Chen, Bin Sun, Junjun Liu, Fan-Yu Meng, Ye Liu, Tian Tian, An Jin, and Han-Li Ruan*, Lignans from the Fruit of Schisandra glaucescens with Antioxidant and Neuroprotective Properties, Journal of Natural Products , 2014, 77 (6): 1311–1320

*  An Jin, Xue Li, Yun-Yun Zhu, Heng-Yi Yu, Hui-Fang Pi, Peng Zhang, Han-Li Ruan* Four New Compounds from the Bulbs of Lycoris aurea with Neuroprotective Effects against CoCl2 and H2O2-induced SH-SY5Y Cell Injuries, Archives of Pharmacal Research 2014, 37: 315-323

*  Wen-Ming Wu, Yun-Yun Zhu, Hao-ran Li, Heng-Yi Yu, Peng Zhang, Hui-Fang Pi, Han-Li Ruan* Two new alkaloids from the bulb of Lycoris sprengeri  Journal of Asian Natural Products Research, 2014, 16(2): 192-199.

*  Heng-Yi Yu, Xiao-Qiong Zhang, Xue-Li, Fan-Bo Zeng, Han-Li Ruan* 2-Methoxyjuglone Induces Apoptosis in HepG2 Human Hepatocellular Carcinoma Cells and Exhibits in Vivo Antitumor Activity in a H22 Mouse Hepatocellular Carcinoma Model, Journal of Natural Products 2013, 76(5): 889−895

*  Juan Li, Jia-Xiang Sun, Heng-Yi Yu, Zu-Yu Chen, Xiao-Ya Zhao, Han-Li Ruan* Diarylheptanoids from the root bark of Juglans cathayensis, Chinese Chemical Letters 2013, 24: 521-523

*  Xue Li, Heng-Yi Yu, Zhuo-Yi Wang, Hui-Fang Pi, Peng Zhang, Han-Li Ruan* Neuroprotective Compounds from the Bulbs of Lycoris radiate, Fitoterapia 2013, 88: 82-90.

*  Heng-Yi Yu, Cui Hao, Fan-Yu Meng, Xue Li, Zu-Yu Chen, Xi Liang, Han-Li Ruan* Neuroprotective Lignans from the Stems of Schisandra glaucescens Planta Medica 2012, 78: 1962-1966

*  Jia-Xiang Sun, Xiao-Ya Zhao, Xiao-Fang Fu, Heng-Yi Yu, Xue Li, Shu-Ming Li, Han-Li Ruan*  Three new naphthalenyl glycosides from the root bark of Juglans cathayensis, Chemical and Pharmaceutical Bulletin  2012, 60: 785-789.

Kathrin Mundt, Beate Wollinsky, Han-Li Ruan, Tianjiao Zhu and Shu-Ming Li, Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches. Chembiochem 2012, Nov 26; 13(17): 2583-2592 (This paper was selected as issue cover)

*  Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Heng-Yi Yu, Shu-Ming Li, and Han-Li Ruan*. Schiglautone A, a New Tricyclic Triterpenoid with a Unique 6/7/9-Fused Skeleton from the Stems of Schisandra glaucescens. Organic Letters, 2011, 13 (6): 1502–1505

*  Fan-Yu Meng, Jia-Xiang Sun, Xue Li, Hui-Fang Pi, Peng Zhang, Han-Li Ruan*. Triterpenoids from the Stems of Schisandra glaucescens. Helvetica Chimica Acta, 2011, 94(10):1778-1785

*  Heng-Yi Yu, Xue Li, Fan-Yu Meng, Hui-Fang Pi, Peng Zhang, Han-Li Ruan* Naphthoquinones from the root barks of Juglans cathayensis Dode. Journal of Asian Natural Products Research, 2011, 13 (7): 581-587.

Han-Li Ruan, Edyta Stec and Shu-Ming Li. Production of diprenylated indole derivatives by tandem incubation of two recombinant dimethylallyltryptophan synthases  Arch. Microb. 2009, 191: 791-795

*  PI Hui-fang, ZHANG Peng, RUAN Han-li*, ZHANG Yong-hui, SUN Han-dong, WU Ji-zhou  A new triterpenoid from the leaves and stems of Fritillaria hupehensis Journal of Asian Natural Products Research  2009, 11 (9): 779-782

Nicola Steffan, Alexander Grundmann, Shamil Afiyatullov, Hanli Ruan and Shu-Ming Li FtmOx1, a non-heme Fe(II) and a-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus  Org. Biomol. Chem. 2009, 7(19): 4082-7

Han-Li Ruan, Wen-Bing Yin, Ji-Zhou Wu, Shu-Ming Li. Reinvestigation of a Cyclic Dipeptide N-Prenyltransferase Reveals Rearrangement of N-1 Prenylated Indole Derivatives. ChemBioChem 2008, 9: 1044-1047.

*  Hui Fang Pi Zhi Hong Zhong Han Li Ruan* Peng Zhang Yong Hui Zhang Ji Zhou Wu A new hopane triterpenoid from Saxiglossum angustissimum  Chinese Chemical Letters 2008, 19: 835–836

*  LI Yi-xiu; RUAN Han-li*; ZHOU Xue-feng; ZHANG Yong-hui; PI Hui-fang and WU Ji-zhou  Cytotoxic Diarylheptanoids from Pericarps of Juglans Cathayensis Dode Chem. Res. Chinese Universities   2008, 24(4), 427 -429

*  Pi, Hui Fang; Zhang, Peng; Zhu, Tian; Ruan, Han Li*; Zhang, Yong Hui; Sun, Han Dong; Wu, Ji Zhou.   A new cycloartane triterpenoid from the leaves and stems of Fritillaria hupehensis. Chinese Chemical Letters  2007, 18(4), 418-420.

Ruan Han-li, Zhang Yong-hui,Wu Ji-zhou. Two new diterpenoid dimers, fritillebinide D and E, from bulbs of fritillaria ebeiensis Journal of Asian Natural Products Research 2002; 4(4): 309-314

Ruan Han-li, Zhang Yong-hui,Wu Ji-zhou. Structure of a novel diterpenoid ester, fritillahupehin, from bulbs of fritillaria hupehensis Hsiao et K. C. Hsia Fitoterapia 2002: 73(4): 288-291

Selected Cases

1002271: Natural Medicinal Chemistry (undergraduate)

1002132: Spectroscopic Analysis (undergraduate)

514.505: Spectroscopic Analysis (graduate)

514.507: Research Methods in Natural Medicinal Chemistry (graduate)

514.515: Extraction and Separation Technology of Chemical Constituents of Traditional Chinese Medicine

Courses Taught

2016.01-2019.12; National Natural Science Foundation of China (21572073)

2013.01-2016.12; National Natural Science Foundation of China (31270394)

2013.01-2015.12; Wuhan Program for Science and Technology (2013060501010158)

2011.1-2013.12; National Natural Science Foundation of China (81072547)

2010.7-2013.6; International Cooperative Project Ministry of Science and Technology of the People’s Republic of China (2010DFA32430)

2009.1-2011.12; National Natural Science Foundation of China (30873361)

2006.1-2007.12; Natural Science Foundation of Hubei Province, China (2006ABA125)

2004.1-2006.12; Hubei Program for Science and Technology (2004AA302B10)

2002.1-2005.12; Wuhan Youth Science and Technology Plan (20025001022)

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