Phone: 027-83692745


Academic Areas: Single-molecule biophysics, Molecular Pharmacology, Nucleic acids, G-quadruplexes

Research Interests: Drugs targeting G-quadruplexes, including anti-cancer drugs, Neurodegeneration diseases related drugs; Development of drug screening methods based on single-molecule techniques.

Academic Degrees

PhD in Biotechnology, Graduate School of Engineering, 2012, Osaka University, Osaka, Japan;

Master in Biotechnology, Graduate School of Engineering, 2008, Osaka University, Osaka, Japan;

Bachelor in Biological Science, Peking University, 2006, Beijing, China.

Professional Experience

Professor (2017-present); School of Pharmaceutical Science, Tongji Medical College, HUST

Research fellow (2013-2017); Mechanobiology Institute, National university of Singapore, Singapore

Project Academic Support Specialist (2011-2013); Department of applied chemistry, School of Engineering, The University of Tokyo, Japan

Selected Publications

  1. You H(#), Lattmann S(#), Rhodes, D(*), Yan J(*). RHAU helicase stabilizes G4 in its nucleotide-free state and destabilizes G4 upon ATP hydrolysis. Nucleic Acids Research  2016, gkw881
  2. You H, Wu J, Shao F, et al. Stability and kinetics of c-MYC promoter G-quadruplexes studied by single-molecule manipulation. Journal of the American Chemical Society, 2015, 137 (7), 2424-2427.
  3. Watanabe R(#), Koyasu K(#), You H, Tanigawara M, Noji H. Torque transmission mechanism via DELSEED loop of F1-ATPase. Biophysical Journal 2015, 108 (5), 1144-1152.
  4. You H, Zeng X, Xu Y, Lim C.J, Efremov A, Phan A.T, Yan J. Dynamics and stability of polymorphic human telomeric G-quadruplex under tension. Nucleic Acids Research 2014, 42 (13), 8789-8795.
  5. You H, Iino R, Watanabe R, Noji H. Winding single-molecule double-stranded DNA on a nanometer-sized reel. Nucleic Acids Research 2012 40 (19): e151. doi: 10.1093/nar/gks651

Courses Taught


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