Associate Professor

Phone: 027-83692745

Email: pmchenzl@hust.edu.cn

Academic Areas: medicinal chemistry, chemical biology

Research Interests: novel and efficient methodology to construct chiral heterocycle, novel small molecules drug design and development

Academic Degrees

PhD in Organic Chemistry, 2013, Hong Kong University of Science and Technology, Hong Kong, China;

MS in Organic Chemistry, 2009, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai, China.

B.S in Applied Chemistry, 2006, Tongji University, Shanghai

Professional Experience

Associate Professor (2016.11-present); Tongji Pharmacy School, HUST

Postdoc Research Associate (2014.11-2016.11) The Elsheman School of Pharmacy, University of North Carolina at Chapel Hill

Postdoc Research Associate (2013.9-2014.10) Department of Chemistry, Duke University

Research Associate (2009.7-2011.1) Shanghai Unitris Biopharm. Co. Ltd

Selected Publications

  1. Bioactive Alkaloid‐Type Polycycles through Efficient Catalytic Asymmetric Multicomponent Aza‐Diels‐Alder Reaction of Indoles with Oxetane as Directing Group,Chen, Z.; Wang, B.; Wang, Z.; Zhu, G.; Sun, J. Angew. Chem., Int. Ed. 2013, 52, 2027‐2031
  2. Enantio- and Diastereoselective Assembly of Tetrahydrofuran and Tetrahydropyran Skeletons with All‐Carbon Quaternary Stereocenters, Chen, Z; Sun, J. Angew. Chem., Int.Ed. 2013, 52, 13593‐13596.
  3. Catalytic Enantioselective Assembly of Tetrahydroisoquinolines and Their Analogues Bearing A C‐4 Stereocenter: A Formal Synthesis of (+)‐(8S,13R)‐Cyclocelabenzine. Chen, Z1.; Wang, Z1.; Sun, J. (1: equal contribution) Chem. Eur. J. 2013, 19, 8426‐8430.
  4. Synthesis of o‐Aminophenols via a Formal Insertion Reaction of Arynes into Hydroxyindolinones, Chen, Z.; Wang, Q. Org. Lett., 2015, 17, 6130.
  5. A Versatile and Highly Stereoselective Synthesis of Diethyl (1‐Aminoalkyl)thiophosphonates ,Chen Z, Li J, Yuan C, Synthesis, 2009, 3939‐3940

Project

Asymmetric Michael addition by photo-catalyst polyoxometalates and small organocatalyst (NSFC 21602011 2017.1-2019.12).

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