Associate Professor

Phone: 027-83692745

Email: yongboxue@mail.hust.edu.cn

Academic Areas: Medicinal Chemistry of Natural Products (NPs)

Research Interests: chemical basis of TCM; structurally novel NPs containing polycyclic hydrocarbon scaffolds; the NPs-based Drug discovery and development for Cancer and neurodegenerative diseases

Yongbo Xue, received PhD degree from the Kunming Institute of Botany under the guidance of Professor & Academia Han-Dong Sun, Chinese Academy of Sciences, where he studied the isolation and structural elucidation of NPs from plants. After finishing Ph.D. of Medicinal Chemistry, Dr. Xue has joined Huazhong University of Science and Technology (HUST) in 2011 and has worked on NPs right through his career. This started with triterpenoids, lignans, and followed by PPAPs, diterpenoids, cytochalasan alkaloids, and meroterpenoids. He has characterized 900 NPs (>330 new compounds) and authorized a number of reputable publications in Angew. Chem. Int. Edit., Chem. Sci., Org. Lett., J. Nat. Prod., J. Org. Chem., Org. Chem. Front., Rsc Adv., Euro. J. Org. Chem., Phytochemistry, Tetrahedron, Tetrahedron Lett., etc. Dr. Xue has been awarded as a young editor of the Chinese core journal of Nat. Prod. Res. Dev., and invited as reviewer for a series of international journals including J. Nat. Prod., Org. Chem. Front., Rsc Adv., Chin. Chem. Lett., Chem. Biodiversity, Helv. Chim. Acta., Food & Function, etc. His current interests include structure elucidation of NPs by spectral and computational methods, and NPs-based medicines research and development. Most recently, his research interest has broadened to NPs from terrestrial/marine fungi.

Academic Degrees

◇ PhD of Medicinal Chemistry, 2008-2011, under the supervisor of Prof. & CAS Academia Han-Dong Sun, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), China;

◇ Master in Medicinal Chemistry, 2005-2008, under the joint supervisors of Prof. Jin-Fu Qian & Prof. Qin-Shi Zhao, School of Pharmacy, Dali University, and Kunming Institute of Botany, Chinese Academy of Sciences (CAS), China;

◇ BSc of Pharmaceutical Science, 2001-2005, School of Pharmacy, Dali University, China.

Professional Experience

◇ Lecturer (2011-2016); Department of Traditional Chinese Medicine & Natural Medicinal Chemistry, School of Pharmacy, Tongji Medical College, HUST

◇ Professor (Associate) (2016-); Department of Traditional Chinese Medicine & Natural Medicinal Chemistry, School of Pharmacy, Tongji Medical College, HUST

Selected Publications

1. Ying Tang(#), Yongbo Xue(#), Guang Du(#), Jianping Wang, Junjun Liu, Bin Sun, Xiao-Nian Li, Guangmin Yao, Zengwei Luo, Yonghui Zhang(*): Structural revisions of a class of natural products: scaffolds of aglycon analogs of fusicoccins and cotylenins isolated from fungi. Angew. Chem. Int. Ed. 2016; 55: 4069–73. DOI: 10.1002/anie.201600313 (JCR2015IF 11.709)

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2016; 36, 742–6.

◇ Abstracted by Cheminform 07/2016; 47(30). DOI:10.1002/chin.201630231

2. Hucheng Zhu(#), Chunmei Chen(#), Yongbo Xue(#), Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao, Zengwei Luo, Yonghui Zhang(*): Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, from Aspergillus flavipes. Angew. Chem. Int. Ed. 2015; 54: 13374–8. DOI: 10.1002/anie.201506264. (JCR2015IF 11.709)

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2016; 33, 122–6.

3. Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong, Xiao-Nian Li, Jing Yang, Yongbo Xue, Zengwei Luo, Jianping Wang, Guangmin Yao, Yonghui Zhang(*): Epicochalasines A and B, Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes. Angew. Chem. Int. Ed. 02/2016; 128: 3547–51. DOI:10.1002/anie.201511315 (JCR2015IF 11.709)

4. Changxing Qi(#), Jian Bao(#), Jianping Wang(#), Hucheng Zhu, Yongbo Xue, Xiaochuan Wang, Hua Li, Weiguang Sun, Weixi Gao, Yongji Lai, Jian-guo Chen, Yonghui Zhang(*): Asperterpenes A and B, Two Unprecedented Meroterpenoids from Aspergillus terreus with BACE1 Inhibitory Activities. Chem. Sci. 10/2016; 7(10): 6563–72. DOI:10.1039/C6SC02464E (JCR2015IF 11.709)

5. Zhengxi Hu(#), Ye Wu(#), Shuangshuang Xie, Weiguang Sun, Yi Guo, Xiaonian Li, Junjun Liu, Hua Li, Jianping Wang, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*): Phomopsterones A and B, Two Highly Functionalized Ergostane-type Steroids from the Endophytic Fungus Phomopsis sp. TJ507A, Org. Lett. 2017; 19(1): 258–61. DOI: 10.1021/acs.orglett.6b03557. (JCR2015IF 6.732)

6. Linzhen Hu(#), Yu Zhang(#), Hucheng Zhu, Junjun Liu, Hua Li, Xiao-Nian Li, Weiguang Sun, Junfen Zeng, Yongbo Xue, Yonghui Zhang(*): Filicinic Acid Based Meroterpenoids with anti-Epstein-Barr Virus Activities from Hypericum japonicum. Org. Lett. 2016; 18(9): 2272–5. DOI: 10.1021/ol503666b. (JCR2015IF 6.732)

◇ Abstracted by Cheminform 09/2016; 47(38). DOI:10.1002/chin.201638191

7. Chunmei Chen(#), Hucheng Zhu(#), Xiao-Nian Li, Jing Yang, JianpingWang, Gentao Li, Yan Li, Qingyi Tong, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum. Org. Lett. 2015; 17(3): 644–7. DOI: 10.1021/ol503666b. (JCR2015IF 6.732)

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2015; 32, 512–6.

◇ Abstracted by Cheminform 06/2015; 46(26). DOI:10.1002/chin.201526261

8. Zheng-Xi Hu(#), Yi-Ming Shi(#), Wei-Guang Wang, Xiao-Nian Li, Xue Du, Miao Liu, Yan Li, Yong-Bo Xue, Yong-Hui Zhang(*), Jian-Xin Pu(*), Han-Dong Sun: Kadcoccinones A−F, New Biogenetically Related Lanostane-Type Triterpenoids with Diverse Skeletons from Kadsura coccinea. Org. Lett. 09/2015; 17(18): 4616–9. DOI:10.1021/acs.orglett.5b02360

9. Ming Yuan, Li Chen, Junwei Wang, Shenjie Chen, Kongchao Wang, Yongbo Xue, Guangmin Yao, Zengwei Luo, Yonghui Zhang: Transition-Metal-Free Synthesis of Phenanthridinones from Biaryl-2-Oxamic Acid under Radical conditions. Org. Lett. 01/2015; 17(2): 346–9. DOI:10.1021/ol503459s

10. Hucheng Zhu, Chunmei Chen, Jing Yang, Xiao-Nian Li, Junjun Liu, Bin Sun, Sheng-Xiong Huang, Dongyan Li, Guangmin Yao, Zengwei Luo, Yan Li, Jinwen Zhang, Yongbo Xue(*), Yonghui Zhang(*): Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum sampsonii. Org. Lett. 2014; 16(23): 6322–5. DOI: 10.1021/ol5030579. (JCR2014IF 6.364)

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2015; 32, 5126.

11. Yi-Ming Shi, Xing-Yao Li, Xiao-Nian Li, Xiao Luo, Yong-Bo Xue, Cheng-Qin Liang, Juan Zou, Ling-Mei Kong, Yan Li, Jian-Xin Pu, Wei-Lie Xiao(*), Han-Dong Sun(*): Schicagenins A-C: Three Cagelike Nortriterpenoids from Leaves and Stems of Schisandra chinensis. Org. Lett. 06/2011; 13(15): 384851.DOI:10.1021/ol201366d

12. Mengke Zhang, Yan Zhu, Guanqun Zhan, Penghua Shu, Rongjian Sa, Liang Lei, Ming Xiang, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao, Yonghui Zhang: Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeleton from Rhododendron micranthum. Org. Lett. 06/2013; 15(12): 3094–7. DOI:10.1021/ol401292y

13. Yongbo Xue, Jian-Hong Yang, Xiao-Nian Li, Xue Du, Jian-Xin Pu(*), Wei-Lie Xiao, Jia Su, Wei Zhao, Yan Li, Han-Dong Sun(*): Henrischinins A–C: three new triterpenoids from Schisandra henryi. Org. Lett. 2011; 13(6): 1564–7. DOI: 10.1021/ol200283y. (JCR2011IF 5.862)

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2011; 28, 1031–4.

14. Yan He(#), Zhengxi Hu(#), Weiguang Sun, Qin Li, Xiao-Nian Li, Hucheng Zhu, Jinfeng Huang, Junjun Liu, Jianping Wang, Yongbo Xue(*), and Yonghui Zhang(*): Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp. TJ23. J. Org. Chem. 02/2017; online, DOI:10.1021/acs.joc.7b00056

15. Yuben Qiao(#), Qianqian Xu(#), Zhengxi Hu, Xiao-Nian Li, Ming Xiang, Junjun Liu, Jinfeng Huang, Hucheng Zhu, Jianping Wang, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*): Diterpenoids of the Cassane Type from Caesalpinia decapetala. J. Nat. Prod. 12/2016; 79 (12): 3134–42. DOI: 10.1021/acs.jnatprod.6b00910. (JCR2015IF 3.662)

16. Guanqun Zhan, Junfei Zhou, Rong Liu, Tingting Liu, Guoli Guo, Jianping Wang, Ming Xiang, Yongbo Xue, Zengwei Luo, Yonghui Zhang, Guangmin Yao(*): Galanthamine, Plicamine, and Secoplicamine Alkaloids from Zephyranthes candida and Their Anti-acetylcholinesterase and Anti-inflammatory Activities. J. Nat. Prod. 02/2016; 79(4): 760–6. DOI:10.1021/acs.jnatprod.5b00681

17. Yuanyuan Lu(#), Yongbo Xue(#)(*), Junjun Liu, Guangmin Yao, Dongyan Li, Bin, Sun, Jinwen Zhang, Yanfei Liu, Changxing Qi, Ming Xiang, Zengwei Luo, Guang Du,(*) Yonghui Zhang(*): (±)-Acortatarinowins A–F, Norlignan, Neolignan, and Lignan Enantiomers from Acorus tatarinowii. J. Nat. Prod. 2015; 78(9): 2205–14. DOI:10.1021/acs.jnatprod.5b00328. (JCR2015IF 3.662)

18. Chunmei Chen, Jianping Wang, Junjun Liu, Hucheng Zhu, Bin Sun, Jing Wang, Jinwen Zhang, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), Yonghui Zhang(*): Armochaetoglobins A–J: cytochalasan alkaloids from Chaetomium globosum TW1-1, a fungus derived from the terrestrial arthropod Armadillidium vulgare. J. Nat. Prod. 2015, 78(6): 1193–201. DOI: 10.1021/np500626x. (JCR2015IF 3.662)

19. Linzhen Hu, Yongbo Xue, Jinwen Zhang, Hucheng Zhu, Chunmei Chen, Xiao−Nian Li, Junjun Liu, Zhenzhen Wang, Yu Zhang(*), Yonghui Zhang(*): (±)-Japonicols A–D, Acylphloroglucinol-based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum. J. Nat. Prod. 2016; 79: 1322–8. DOI: 10.1021/acs.jnatprod.5b01119. (JCR2015IF 6.732)

20. Junfen Zeng, Yongbo Xue, Penghua Shu, Huiqin Qian, Rongjian Sa, Ming Xiang, Xiao-Nian Li, Zengwei Luo, Guangmin Yao(*), Yonghui Zhang(*): Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia. J. Nat. Prod. 2014; 77(8): 144854. DOI: 10.1021/np500465g.

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2014; 31: 706–10

21. Heng Zheng, Qiong Chen, Mengke Zhang, Yongji Lai, Liang Lei, Penghua Shu, Jinwen Zhang, Yongbo Xue, Zengwei Luo, Yan Li, Guangmin Yao, Yonghui Zhang: Correction to Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei. J. Nat. Prod. 12/2013; 76(12): 76(12): 225362. DOI:10.1021/np401015a

22. Yongji Lai, Tingting Liu, Rongjian Sa, Xialan Wei, Yongbo Xue, Zhaodi Wu, Zengwei Luo, Ming Xiang, Yonghui Zhang, Guangmin Yao: Neolignans with a Rare 2-Oxaspiro[4.5]deca-6,9-dien-8-one Motif from the Stem Bark of Cinnamomum subavenium. J. Nat. Prod. 06/2015; 78(8): 1740–4. DOI:10.1021/np5010533

23. Penghua Shu, Xialan Wei, Yongbo Xue, Weijie Li, Jinwen Zhang, Ming Xiang, Mengke Zhang, Zengwei Luo, Yan Li, Guangmin Yao(*), Yonghui Zhang(*): Wilsonols A–L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii. J. Nat. Prod. 2013; 76(7): 130312. DOI: 10.1021/np4002493.

24. Wei Zhao, Jian-Xin Pu(*), Xue Du, Jia Su, Xiao-Nian Li, Jian-Hong Yang, Yong-Bo Xue, Yan Li, Wei-Lie Xiao, Han-Dong Sun(*): Structure and Cytotoxicity of Diterpenoids from Isodon adenolomus. J. Nat. Prod. 05/2011; 74(5): 1213–20. DOI:10.1021/np200140j

25. Jian-Hong Yang, Jian-Xin Pu(*), Jin Wen, Xiao-Nian Li, Fei He, Yong-Bo Xue, Yuan-Yuan Wang, Yan Li, Wei-Lie Xiao, Han-Dong Sun(*): Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma. J. Nat. Prod. 12/2009; 73(1)., DOI:10.1021/np900506g

26. Yongbo Xue, Xifeng Li, Xue Du, Xiaonian Li, Weiguang Wang, Jianhong Yang, Jijun Chen, Jianxin Pu(*), Handong Sun(*): Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis. Phytochemistry 2015; 116: 253–61. DOI: 10.1016/j.phytochem.2015.03.009. (JCR2015IF 2.779)

27. Hucheng Zhu(#), Chunmei Chen(#), Junjun Liu, Bin Sun, Guangzheng Wei, Yan Li, Jinwen Zhang, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Hyperascyrones A–H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn. Phytochemistry 2015, 115: 222–30. DOI: 10.1016/j.phytochem.2015.02.009. (JCR2015IF 2.779)

28. Yongji Lai(#), Yongbo Xue(#), Mengke Zhang, Jinwen Zhang, Wei Tang, Junjun Liu, Liang Lei, Juming Yan, Zengwei Luo, Jianping Zuo, Yan Li, Guangmin Yao(*), Yonghui Zhang(*): Scapiformolactones A–I: Germacrane sesquiterpenoids with an unusual Δ(3)-15,6-lactone moiety from Salvia scapiformis. Phytochemistry 2013; 96: 37888. DOI: 10.1016/j.phytochem.2013.10.003. (JCR2013IF 3.350)

29. Mengke Zhang, Yangyang Xie, Guanqun Zhan, Liang Lei, Penghua Shu, Yongli Chen, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao(*), Yonghui Zhang(*): Grayanane and leucothane diterpenoids from the leaves of Rhododendron micranthum. Phytochemistry 06/2015; 177: 107–15. DOI:10.1016/j.phytochem.2015.06.007

30. Zhaodi Wu(#), Yongji Lai(#), Lei Zhou, Ye Wu, Hucheng Zhu, Zhengxi Hu, Jing Yang, Jinwen Zhang, Jianping Wang, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Enantiomeric Lignans and Neolignans from Phyllanthus glaucus: Enantioseparation and Their Absolute Configurations. Sci. Rep.-UK 04/2016; 6: 24809. DOI: 10.1038/srep24809. (JCR2015IF 5.228)

31. Linzhen Hu(#), Hucheng Zhu(#), Lei Li(#), Jinfeng Huang, Weiguang Sun, Junjun Liu, Hua Li, Zengwei Luo, Jianping Wang, Yongbo Xue(*), Yu Zhang(*), Yonghui Zhang(*): (±)-Japonones A and B, two pairs of new enantiomers with anti-KSHV activities from Hypericum japonicum. Sci. Rep.-UK 06/2016; 6: 27588. DOI: 10.1038/srep27588. (JCR2015IF 5.228)

32. Weiguang Sun(#), Xintao Chen(#), Qingyi Tong(#), Hucheng Zhu(#), Yan He, Liang Lei, Yongbo Xue, Guangmin Yao, Zengwei Luo, Jianping Wang(*), Hua Li(*), Yonghui Zhang(*): Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune. Sci. Rep.-UK 05/2016; 6: 26418. DOI:10.1038/srep26418

33. Guangzheng Wei(#), Dongdong Tan(#), Chunmei Chen, Qingyi Tong, Xiao-Nian Li, Jinfeng Huang, Junjun Liu, Yongbo Xue, Jianping Wang, Zengwei Luo, Hucheng Zhu(*), Yonghui Zhang(*): Flavichalasines A–M, cytochalasan alkaloids from Aspergillus flavipes. Sci. Rep.-UK 02/2017; 7: 42434. DOI:10.1038/srep42434

34. Yuanyuan Lu, Yongbo Xue, Shenjie Chen, Hucheng Zhu, Jinwen Zhang, Xiao-Nian Li, Jianping Wang, JunJun Liu, Changxing Qi, Guang Du, Yonghui Zhang: Antioxidant Lignans and Neolignans from Acorus tatarinowii. Sci. Rep.-UK 03/2016; 6: 22909. DOI:10.1038/srep22909

35. Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong, Xintao Chen, Jing Yang, Junjun Liu, Bin Sun, Jianping Wang, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Hyperisampsins H−M, cytotoxic polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii. Sci. Rep.-UK 2015; 5: 14772.

36. Liang Lei(#), Yongbo Xue(#), Zhong Liu, Sisi Peng, Yan He, Yang Zhang, Rong Fang, Jianping Wang, Zengwei Luo, Guangmin Yao, Jinwen Zhang, Geng Zhang, Hongping Song,(*) Yonghui Zhang(*): Coumarin derivatives from Ainsliaea fragrans and their anticoagulant activity. Sci. Rep.-UK 2015; 5: 13544. DOI:10.1038/srep13544.

37. Hucheng Zhu(#), Chunmei Chen(#), Dongdong Tan, Dongyan Li, Yi Guo, Guangzheng Wei, Jinwen Zhang, Jianping Wang, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Sampbenzophenones A–G, prenylated benzoylphloroglucinol derivatives from Hypericum sampsonii. Rsc Adv. 01/2016; 6(89): 86710–6. DOI: 10.1039/C6RA17885E. (JCR2015IF 3.289)

38. Dongyan Li(#), Yongbo Xue(#), Hucheng Zhu, Yan Li, Bin Sun, Junjun Liu, Guangmin Yao, Jinwen Zhang, Guang Du(*), Yonghui Zhang(*): Hyperattenins A–I, Bioactive Polyprenylated Acylphloroglucinols from Hypericum attenuatum Choisy. RSC Adv. 2015; 5: 5277–87. DOI: 10.1039/C4RA11675E. (JCR2015IF 3.289)

39. Chunmei Chen, Hucheng Zhu, Jianping Wang, Jing Yang, Xiao-Nian Li, Jing Wang, Keliang Chen, Yanyan Wang, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), Yonghui Zhang(*): Armochaetoglobins K–R, Anti-HIV Pyrrole-based Cytochalasans from Chaetomium Globosum TW1-1. Euro. J. Org. Chem. 2015; 14: 3086–94. DOI: 10.1002/ejoc.201403678. (JCR2015IF 3.086)

40. Hucheng Zhu(#), Chunmei(#), Jing Yang(#), Dongyan Li, Jinwen Zhang, Yi Guo, Jianping Wang, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Hyperhexanone A, a crucial intermediate from bicyclo[3.3.1]- to cyclohexanone monocyclic-polycyclic polyprenylated acylphloroglucinols. Tetrahedron, 2016, 72: 4655–9. DOI: 10.1016/j.tet.2016.06.035. (JCR2015IF 2.645)

41. Dongyan Li, Hucheng Zhu, Changxing Qi, Yongbo Xue(*), Guangmin Yao, Zengwei Luo, Jianping Wang, Jinwen Zhang, Guang Du(*), Yonghui Zhang(*): Two New Adamantyl-Like Polyprenylated Acylphloroglucinols from Hypericum attenuatum choisy. Tetrahedron Lett. 2015; 56(15): 1953–5. DOI: 10.1016/j.tetlet.2015.02.056. (JCR2015IF 2.347)

42. Hucheng Zhu, Lijun Huan, Chunmei Chen, Jing Yang, Jiangbo He, Yong Chen, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): A pair of unprecedented cyclohexylethanoid enantiomers containing unusual trioxabicyclo[4.2.1]nonane ring from Clerodendrum bungei. Tetrahedron Lett. 2014; 55(14): 2277–9. DOI: 10.1002/chin.201437219. (JCR2014IF 2.379)

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2014; 31: 706–10

43. Zhengxi Hu, Jianping Wang, Xiaobin Bi, Jinwen Zhang, Yongbo Xue(*), Yingda Yang, Zengwei Luo, Guangmin Yao, Yonghui Zhang(*): Colletotrichumine A, a novel indole–pyrazine alkaloid with an unprecedented C16N3-type skeleton from cultures of Colletotrichum capsici. Tetrahedron Lett. 2014; 55(44): 6093–5. DOI: 10.1016/j.tetlet.2014.09.041. (JCR2014IF 2.379)

44. Zheng-Xi Hu(#), Yongbo Xue(#), Xiao-Bin Bi, Jin-Wen Zhang, Zeng-Wei Luo, Xiao-Nian Li, Guang-Min Yao, Jian-Ping Wang(*), Yong-Hui Zhang(*): Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii. Mar. Drugs 2014; 12(11): 5563–75. DOI: 10.3390/md12115563. (JCR2014IF 2.853)

45. Yongbo Xue(*), Ye Wu, Hucheng Zhu, Xiao-Nian Li, Jin-Fu Qian, Yongji Lai, Chunmei Chen, Guangmin Yao, Zengwei Luo, Yan Li, Yonghui Zhang(*): Salviprzols A and B, C21- and C22-terpenoids from the roots of Salvia przewalskii Maxim. Fitoterapia 2014; 99: 204–10. DOI: 10.1016/j.fitote.2014.09.022. (JCR2014IF 2.345)

46. Chunmei Chen, Guangzheng Wei, Hucheng Zhu, Yi Guo, Xiao-Nian Li, Jinwen Zhang, Yanfei Liu, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*): A new 3,4-seco-oleanane-type triterpenoid with an unusual enedione moiety from Hypericum ascyron. Fitoterapia 2015; 103: 227-30. DOI: 10.1016/j.fitote.2015.04.009. (JCR2015IF 2.408)

47. Hu-Cheng Zhu(#), Chun-Mei Chen(#), Jin-Wen Zhang, Yi Guo, Dong-Dong Tan, Guang-Zheng Wei, Jing Yang, Jian-Ping Wang, Zeng-Wei Luo, Yong-Bo Xue(*), and Yong-Hui Zhang(*): Hyperisampsins N and O, Two New Benzoylated Phloroglucinol Derivatives from Hypericum sampsonii. Chinese Chem. Lett. 2016; Ahead of print. (JCR2015IF 1.947)

◇ Abstracted by Cheminform 11/2016; 47(47). DOI:10.1002/chin.201647217

48. Hucheng Zhu(#), Chunmei Chen(#), Jianping Wang, Xiao-Nian Li, Guangzheng Wei, Yi Guo, Guangmin Yao, Zengwei Luo, Jinwen Zhang, Yongbo Xue(*), Yonghui Zhang(*): Penicamedine A, a highly oxygenated hexacyclic indole alkaloid from Penicillium camemberti. Chem. Biodiversity. 2015; 12: 1547−53. DOI: 10.1002/cbdv.201400412.

49. Zhengxi Hu, Yongji Lai, Jinwen Zhang, Ye Wu, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), Yonghui Zhang(*): Phytochemical and chemotaxonomic studies on Phyllanthus urinaria. Biochem. System. Ecol. 2014; 56: 60–4. DOI: 10.1016/j.bse.2014.04.016.

50. Junfen Zeng(#), Yongbo Xue(#), Yongji Lai, Guangmin Yao, Zengwei Luo, Yonghui Zhang, and Jinwen Zhang(*): A new phenolic glycoside from the barks of Cinnamomum cassia. Molecules 09/2014; 19(11): 17727–34. DOI: 10.3390/molecules191117727.

51. Ying Tang, Yongbo Xue, Lei Zhou, Jin-Wen Zhang, Guang-Min Yao, Zeng-Wei Luo, Guang Du(*), Yong-Hui Zhang(*): New Norclerodane Diterpenoids from the Tubers of Dioscorea bulbifera. Chem. Pharm. Bull. 2014; 62(7): 719–24. DOI: 10.1002/chin.201452192.

◇ Abstracted by Cheminform 2014; 45(52): DOI: 10.1002/chin.201452192

52. Yongbo Xue, Yan-Long Zhang, Jian-Hong Yang, Xue Du, Jian-Xin Pu(*), Wei Zhao, Xiao-Nian Li, Wei-Lie Xiao, Han-Dong Sun(*): Nortriterpenoids and lignans from the fruit of Schisandra chinensis. Chem. Pharm. Bull. 2010; 58(12): 1606–11. DOI: 10.1002/chin.201118171.

◇ Abstracted by Cheminform 12/2010; 58(12). DOI:10.1002/chin.201118171

Courses Taught

◇ 514.507: Methods and Principles in Natural Medicinal Chemistry

◇ 1002271: Medicinal Chemistry of Natural Products

◇ 1002132: Spectroscopy of Organic Compounds

Project

◇ Investigation for the discovery of novel anti-Alzheimer’s disease agents from Hypericum plants and their potential mechanisms of action through BACE1/GSK-3β and related signaling pathways (NSFC 81641129, 2017.1-2017.12).

◇ Studies on the chemical constituents and Bioactivities of Phyllanthus species from Huazhong Area (NSFC 31200258, 2013.1-2015.12).

◇ The Fundamental Research Fund for the Central Universities (Nos. 2012QN012, 2014QN128, and 2016YXMS149)

◇ Hubei Provincial Natural Science Foundation of China (2012FFB02333)

◇ The Visiting Scholarship Program of the China Scholarship Council (No. 201606165021)

◇ Scientific Research Foundation of the Huazhong University of Science and Technology (HUST0124514026)

In The Media

ResearchGate ID: https://www.researchgate.net/profile/Yongbo_Xue/info

ORCID ID: 0000-0001-9133-6439

Office Address: Room 507, Building 1, School of Pharmacy, HUST, Hangkong Road 13, Wuhan, China (430030)

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