Xue Yongbo

Associate Professor

Phone: 027-83692745

Email: yongboxue@mail.hust.edu.cn

Academic Areas:Medicinal Chemistry of Natural Products (NPs)

Research Interests:chemical basis of TCM; structurally novel NPs containing polycyclic hydrocarbon scaffolds; the NPs-based Drug discovery and development for Cancer and neurodegenerative diseases

Academic Degrees

◇ PhD of Medicinal Chemistry, 2008-2011, under the supervisor of Prof. & CAS Academia Han-Dong Sun, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), China;

◇ Master in Medicinal Chemistry, 2005-2008, under the joint supervisors of Prof. Jin-Fu Qian & Prof. Qin-Shi Zhao, School of Pharmacy, Dali University, and Kunming Institute of Botany, Chinese Academy of Sciences (CAS), China;

◇ BSc of Pharmaceutical Science, 2001-2005, School of Pharmacy, Dali University, China.

Professional Experience

◇ Lecturer (2011-2016); Department of Traditional Chinese Medicine & Natural Medicinal Chemistry, School of Pharmacy, Tongji Medical College, HUST

◇ Professor (Associate) (2016-); Department of Traditional Chinese Medicine & Natural Medicinal Chemistry, School of Pharmacy, Tongji Medical College, HUST

Selected Publications

1. Ying Tang(#), Yongbo Xue(#), Guang Du(#), Jianping Wang, Junjun Liu, Bin Sun, Xiao-Nian Li, Guangmin Yao, Zengwei Luo, Yonghui Zhang(*): Structural revisions of a class of natural products: scaffolds of aglycon analogs of fusicoccins and cotylenins isolated from fungi. Angew. Chem. Int. Ed. 2016; 55: 4069–73. DOI: 10.1002/anie.201600313 (JCR2015IF 11.709)

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2016; 36, 742–6.

◇ Abstracted by Cheminform 07/2016; 47(30). DOI:10.1002/chin.201630231

2. Hucheng Zhu(#), Chunmei Chen(#), Yongbo Xue(#), Qingyi Tong, Xiao-Nian Li, Xintao Chen, Jianping Wang, Guangmin Yao, Zengwei Luo, Yonghui Zhang(*): Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, from Aspergillus flavipes. Angew. Chem. Int. Ed. 2015; 54: 13374–8. DOI: 10.1002/anie.201506264. (JCR2015IF 11.709)

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2016; 33, 122–6.

3. Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong, Xiao-Nian Li, Jing Yang, Yongbo Xue, Zengwei Luo, Jianping Wang, Guangmin Yao, Yonghui Zhang(*): Epicochalasines A and B, Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes. Angew. Chem. Int. Ed. 02/2016; 128: 3547–51. DOI:10.1002/anie.201511315 (JCR2015IF 11.709)

4. Changxing Qi(#), Jian Bao(#), Jianping Wang(#), Hucheng Zhu, Yongbo Xue, Xiaochuan Wang, Hua Li, Weiguang Sun, Weixi Gao, Yongji Lai, Jian-guo Chen, Yonghui Zhang(*): Asperterpenes A and B, Two Unprecedented Meroterpenoids from Aspergillus terreus with BACE1 Inhibitory Activities. Chem. Sci. 10/2016; 7(10): 6563–72. DOI:10.1039/C6SC02464E (JCR2015IF 11.709)

5. Zhengxi Hu(#), Ye Wu(#), Shuangshuang Xie, Weiguang Sun, Yi Guo, Xiaonian Li, Junjun Liu, Hua Li, Jianping Wang, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*): Phomopsterones A and B, Two Highly Functionalized Ergostane-type Steroids from the Endophytic Fungus Phomopsis sp. TJ507A, Org. Lett. 2017; 19(1): 258–61. DOI: 10.1021/acs.orglett.6b03557. (JCR2015IF 6.732)

6. Linzhen Hu(#), Yu Zhang(#), Hucheng Zhu, Junjun Liu, Hua Li, Xiao-Nian Li, Weiguang Sun, Junfen Zeng, Yongbo Xue, Yonghui Zhang(*): Filicinic Acid Based Meroterpenoids with anti-Epstein-Barr Virus Activities from Hypericum japonicum. Org. Lett. 2016; 18(9): 2272–5. DOI: 10.1021/ol503666b. (JCR2015IF 6.732)

◇ Abstracted by Cheminform 09/2016; 47(38). DOI:10.1002/chin.201638191

7. Chunmei Chen(#), Hucheng Zhu(#), Xiao-Nian Li, Jing Yang, JianpingWang, Gentao Li, Yan Li, Qingyi Tong, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Armochaeglobines A and B, two new indole-based alkaloids from the arthropod-derived fungus Chaetomium globosum. Org. Lett. 2015; 17(3): 644–7. DOI: 10.1021/ol503666b. (JCR2015IF 6.732)

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2015; 32, 512–6.

◇ Abstracted by Cheminform 06/2015; 46(26). DOI:10.1002/chin.201526261

8. Zheng-Xi Hu(#), Yi-Ming Shi(#), Wei-Guang Wang, Xiao-Nian Li, Xue Du, Miao Liu, Yan Li, Yong-Bo Xue, Yong-Hui Zhang(*), Jian-Xin Pu(*), Han-Dong Sun: Kadcoccinones A−F, New Biogenetically Related Lanostane-Type Triterpenoids with Diverse Skeletons from Kadsura coccinea. Org. Lett. 09/2015; 17(18): 4616–9. DOI:10.1021/acs.orglett.5b02360

9. Ming Yuan, Li Chen, Junwei Wang, Shenjie Chen, Kongchao Wang, Yongbo Xue, Guangmin Yao, Zengwei Luo, Yonghui Zhang: Transition-Metal-Free Synthesis of Phenanthridinones from Biaryl-2-Oxamic Acid under Radical conditions. Org. Lett. 01/2015; 17(2): 346–9. DOI:10.1021/ol503459s

10. Hucheng Zhu, Chunmei Chen, Jing Yang, Xiao-Nian Li, Junjun Liu, Bin Sun, Sheng-Xiong Huang, Dongyan Li, Guangmin Yao, Zengwei Luo, Yan Li, Jinwen Zhang, Yongbo Xue(*), Yonghui Zhang(*): Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum sampsonii. Org. Lett. 2014; 16(23): 6322–5. DOI: 10.1021/ol5030579. (JCR2014IF 6.364)

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2015; 32, 5126.

11. Yi-Ming Shi, Xing-Yao Li, Xiao-Nian Li, Xiao Luo, Yong-Bo Xue, Cheng-Qin Liang, Juan Zou, Ling-Mei Kong, Yan Li, Jian-Xin Pu, Wei-Lie Xiao(*), Han-Dong Sun(*): Schicagenins A-C: Three Cagelike Nortriterpenoids from Leaves and Stems of Schisandra chinensis. Org. Lett. 06/2011; 13(15): 384851.DOI:10.1021/ol201366d

12. Mengke Zhang, Yan Zhu, Guanqun Zhan, Penghua Shu, Rongjian Sa, Liang Lei, Ming Xiang, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao, Yonghui Zhang: Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeleton from Rhododendron micranthum. Org. Lett. 06/2013; 15(12): 3094–7. DOI:10.1021/ol401292y

13. Yongbo Xue, Jian-Hong Yang, Xiao-Nian Li, Xue Du, Jian-Xin Pu(*), Wei-Lie Xiao, Jia Su, Wei Zhao, Yan Li, Han-Dong Sun(*): Henrischinins A–C: three new triterpenoids from Schisandra henryi. Org. Lett. 2011; 13(6): 1564–7. DOI: 10.1021/ol200283y. (JCR2011IF 5.862)

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2011; 28, 1031–4.

14. Yan He(#), Zhengxi Hu(#), Weiguang Sun, Qin Li, Xiao-Nian Li, Hucheng Zhu, Jinfeng Huang, Junjun Liu, Jianping Wang, Yongbo Xue(*), and Yonghui Zhang(*): Spiroaspertrione A, a Bridged Spirocyclic Meroterpenoid as a Potent Potentiator of Oxacillin against Methicillin-Resistant Staphylococcus aureus from Aspergillus sp. TJ23. J. Org. Chem. 02/2017; online, DOI:10.1021/acs.joc.7b00056

15. Yuben Qiao(#), Qianqian Xu(#), Zhengxi Hu, Xiao-Nian Li, Ming Xiang, Junjun Liu, Jinfeng Huang, Hucheng Zhu, Jianping Wang, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*): Diterpenoids of the Cassane Type from Caesalpinia decapetala. J. Nat. Prod. 12/2016; 79 (12): 3134–42. DOI: 10.1021/acs.jnatprod.6b00910. (JCR2015IF 3.662)

16. Guanqun Zhan, Junfei Zhou, Rong Liu, Tingting Liu, Guoli Guo, Jianping Wang, Ming Xiang, Yongbo Xue, Zengwei Luo, Yonghui Zhang, Guangmin Yao(*): Galanthamine, Plicamine, and Secoplicamine Alkaloids from Zephyranthes candida and Their Anti-acetylcholinesterase and Anti-inflammatory Activities. J. Nat. Prod. 02/2016; 79(4): 760–6. DOI:10.1021/acs.jnatprod.5b00681

17. Yuanyuan Lu(#), Yongbo Xue(#)(*), Junjun Liu, Guangmin Yao, Dongyan Li, Bin, Sun, Jinwen Zhang, Yanfei Liu, Changxing Qi, Ming Xiang, Zengwei Luo, Guang Du,(*) Yonghui Zhang(*): (±)-Acortatarinowins A–F, Norlignan, Neolignan, and Lignan Enantiomers from Acorus tatarinowii. J. Nat. Prod. 2015; 78(9): 2205–14. DOI:10.1021/acs.jnatprod.5b00328. (JCR2015IF 3.662)

18. Chunmei Chen, Jianping Wang, Junjun Liu, Hucheng Zhu, Bin Sun, Jing Wang, Jinwen Zhang, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), Yonghui Zhang(*): Armochaetoglobins A–J: cytochalasan alkaloids from Chaetomium globosum TW1-1, a fungus derived from the terrestrial arthropod Armadillidium vulgare. J. Nat. Prod. 2015, 78(6): 1193–201. DOI: 10.1021/np500626x. (JCR2015IF 3.662)

19. Linzhen Hu, Yongbo Xue, Jinwen Zhang, Hucheng Zhu, Chunmei Chen, Xiao−Nian Li, Junjun Liu, Zhenzhen Wang, Yu Zhang(*), Yonghui Zhang(*): (±)-Japonicols A–D, Acylphloroglucinol-based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum. J. Nat. Prod. 2016; 79: 1322–8. DOI: 10.1021/acs.jnatprod.5b01119. (JCR2015IF 6.732)

20. Junfen Zeng, Yongbo Xue, Penghua Shu, Huiqin Qian, Rongjian Sa, Ming Xiang, Xiao-Nian Li, Zengwei Luo, Guangmin Yao(*), Yonghui Zhang(*): Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia. J. Nat. Prod. 2014; 77(8): 144854. DOI: 10.1021/np500465g.

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2014; 31: 706–10

21. Heng Zheng, Qiong Chen, Mengke Zhang, Yongji Lai, Liang Lei, Penghua Shu, Jinwen Zhang, Yongbo Xue, Zengwei Luo, Yan Li, Guangmin Yao, Yonghui Zhang: Correction to Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei. J. Nat. Prod. 12/2013; 76(12): 76(12): 225362. DOI:10.1021/np401015a

22. Yongji Lai, Tingting Liu, Rongjian Sa, Xialan Wei, Yongbo Xue, Zhaodi Wu, Zengwei Luo, Ming Xiang, Yonghui Zhang, Guangmin Yao: Neolignans with a Rare 2-Oxaspiro[4.5]deca-6,9-dien-8-one Motif from the Stem Bark of Cinnamomum subavenium. J. Nat. Prod. 06/2015; 78(8): 1740–4. DOI:10.1021/np5010533

23. Penghua Shu, Xialan Wei, Yongbo Xue, Weijie Li, Jinwen Zhang, Ming Xiang, Mengke Zhang, Zengwei Luo, Yan Li, Guangmin Yao(*), Yonghui Zhang(*): Wilsonols A–L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii. J. Nat. Prod. 2013; 76(7): 130312. DOI: 10.1021/np4002493.

24. Wei Zhao, Jian-Xin Pu(*), Xue Du, Jia Su, Xiao-Nian Li, Jian-Hong Yang, Yong-Bo Xue, Yan Li, Wei-Lie Xiao, Han-Dong Sun(*): Structure and Cytotoxicity of Diterpenoids from Isodon adenolomus. J. Nat. Prod. 05/2011; 74(5): 1213–20. DOI:10.1021/np200140j

25. Jian-Hong Yang, Jian-Xin Pu(*), Jin Wen, Xiao-Nian Li, Fei He, Yong-Bo Xue, Yuan-Yuan Wang, Yan Li, Wei-Lie Xiao, Han-Dong Sun(*): Cytotoxic Triterpene Dilactones from the Stems of Kadsura ananosma. J. Nat. Prod. 12/2009; 73(1)., DOI:10.1021/np900506g

26. Yongbo Xue, Xifeng Li, Xue Du, Xiaonian Li, Weiguang Wang, Jianhong Yang, Jijun Chen, Jianxin Pu(*), Handong Sun(*): Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis. Phytochemistry 2015; 116: 253–61. DOI: 10.1016/j.phytochem.2015.03.009. (JCR2015IF 2.779)

27. Hucheng Zhu(#), Chunmei Chen(#), Junjun Liu, Bin Sun, Guangzheng Wei, Yan Li, Jinwen Zhang, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Hyperascyrones A–H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn. Phytochemistry 2015, 115: 222–30. DOI: 10.1016/j.phytochem.2015.02.009. (JCR2015IF 2.779)

28. Yongji Lai(#), Yongbo Xue(#), Mengke Zhang, Jinwen Zhang, Wei Tang, Junjun Liu, Liang Lei, Juming Yan, Zengwei Luo, Jianping Zuo, Yan Li, Guangmin Yao(*), Yonghui Zhang(*): Scapiformolactones A–I: Germacrane sesquiterpenoids with an unusual Δ(3)-15,6-lactone moiety from Salvia scapiformis. Phytochemistry 2013; 96: 37888. DOI: 10.1016/j.phytochem.2013.10.003. (JCR2013IF 3.350)

29. Mengke Zhang, Yangyang Xie, Guanqun Zhan, Liang Lei, Penghua Shu, Yongli Chen, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao(*), Yonghui Zhang(*): Grayanane and leucothane diterpenoids from the leaves of Rhododendron micranthum. Phytochemistry 06/2015; 177: 107–15. DOI:10.1016/j.phytochem.2015.06.007

30. Zhaodi Wu(#), Yongji Lai(#), Lei Zhou, Ye Wu, Hucheng Zhu, Zhengxi Hu, Jing Yang, Jinwen Zhang, Jianping Wang, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Enantiomeric Lignans and Neolignans from Phyllanthus glaucus: Enantioseparation and Their Absolute Configurations. Sci. Rep.-UK 04/2016; 6: 24809. DOI: 10.1038/srep24809. (JCR2015IF 5.228)

31. Linzhen Hu(#), Hucheng Zhu(#), Lei Li(#), Jinfeng Huang, Weiguang Sun, Junjun Liu, Hua Li, Zengwei Luo, Jianping Wang, Yongbo Xue(*), Yu Zhang(*), Yonghui Zhang(*): (±)-Japonones A and B, two pairs of new enantiomers with anti-KSHV activities from Hypericum japonicum. Sci. Rep.-UK 06/2016; 6: 27588. DOI: 10.1038/srep27588. (JCR2015IF 5.228)

32. Weiguang Sun(#), Xintao Chen(#), Qingyi Tong(#), Hucheng Zhu(#), Yan He, Liang Lei, Yongbo Xue, Guangmin Yao, Zengwei Luo, Jianping Wang(*), Hua Li(*), Yonghui Zhang(*): Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune. Sci. Rep.-UK 05/2016; 6: 26418. DOI:10.1038/srep26418

33. Guangzheng Wei(#), Dongdong Tan(#), Chunmei Chen, Qingyi Tong, Xiao-Nian Li, Jinfeng Huang, Junjun Liu, Yongbo Xue, Jianping Wang, Zengwei Luo, Hucheng Zhu(*), Yonghui Zhang(*): Flavichalasines A–M, cytochalasan alkaloids from Aspergillus flavipes. Sci. Rep.-UK 02/2017; 7: 42434. DOI:10.1038/srep42434

34. Yuanyuan Lu, Yongbo Xue, Shenjie Chen, Hucheng Zhu, Jinwen Zhang, Xiao-Nian Li, Jianping Wang, JunJun Liu, Changxing Qi, Guang Du, Yonghui Zhang: Antioxidant Lignans and Neolignans from Acorus tatarinowii. Sci. Rep.-UK 03/2016; 6: 22909. DOI:10.1038/srep22909

35. Hucheng Zhu(#), Chunmei Chen(#), Qingyi Tong, Xintao Chen, Jing Yang, Junjun Liu, Bin Sun, Jianping Wang, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Hyperisampsins H−M, cytotoxic polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii. Sci. Rep.-UK 2015; 5: 14772.

36. Liang Lei(#), Yongbo Xue(#), Zhong Liu, Sisi Peng, Yan He, Yang Zhang, Rong Fang, Jianping Wang, Zengwei Luo, Guangmin Yao, Jinwen Zhang, Geng Zhang, Hongping Song,(*) Yonghui Zhang(*): Coumarin derivatives from Ainsliaea fragrans and their anticoagulant activity. Sci. Rep.-UK 2015; 5: 13544. DOI:10.1038/srep13544.

37. Hucheng Zhu(#), Chunmei Chen(#), Dongdong Tan, Dongyan Li, Yi Guo, Guangzheng Wei, Jinwen Zhang, Jianping Wang, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Sampbenzophenones A–G, prenylated benzoylphloroglucinol derivatives from Hypericum sampsonii. Rsc Adv. 01/2016; 6(89): 86710–6. DOI: 10.1039/C6RA17885E. (JCR2015IF 3.289)

38. Dongyan Li(#), Yongbo Xue(#), Hucheng Zhu, Yan Li, Bin Sun, Junjun Liu, Guangmin Yao, Jinwen Zhang, Guang Du(*), Yonghui Zhang(*): Hyperattenins A–I, Bioactive Polyprenylated Acylphloroglucinols from Hypericum attenuatum Choisy. RSC Adv. 2015; 5: 5277–87. DOI: 10.1039/C4RA11675E. (JCR2015IF 3.289)

39. Chunmei Chen, Hucheng Zhu, Jianping Wang, Jing Yang, Xiao-Nian Li, Jing Wang, Keliang Chen, Yanyan Wang, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), Yonghui Zhang(*): Armochaetoglobins K–R, Anti-HIV Pyrrole-based Cytochalasans from Chaetomium Globosum TW1-1. Euro. J. Org. Chem. 2015; 14: 3086–94. DOI: 10.1002/ejoc.201403678. (JCR2015IF 3.086)

40. Hucheng Zhu(#), Chunmei(#), Jing Yang(#), Dongyan Li, Jinwen Zhang, Yi Guo, Jianping Wang, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): Hyperhexanone A, a crucial intermediate from bicyclo[3.3.1]- to cyclohexanone monocyclic-polycyclic polyprenylated acylphloroglucinols. Tetrahedron, 2016, 72: 4655–9. DOI: 10.1016/j.tet.2016.06.035. (JCR2015IF 2.645)

41. Dongyan Li, Hucheng Zhu, Changxing Qi, Yongbo Xue(*), Guangmin Yao, Zengwei Luo, Jianping Wang, Jinwen Zhang, Guang Du(*), Yonghui Zhang(*): Two New Adamantyl-Like Polyprenylated Acylphloroglucinols from Hypericum attenuatum choisy. Tetrahedron Lett. 2015; 56(15): 1953–5. DOI: 10.1016/j.tetlet.2015.02.056. (JCR2015IF 2.347)

42. Hucheng Zhu, Lijun Huan, Chunmei Chen, Jing Yang, Jiangbo He, Yong Chen, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), Yonghui Zhang(*): A pair of unprecedented cyclohexylethanoid enantiomers containing unusual trioxabicyclo[4.2.1]nonane ring from Clerodendrum bungei. Tetrahedron Lett. 2014; 55(14): 2277–9. DOI: 10.1002/chin.201437219. (JCR2014IF 2.379)

◇ Highlighted as Hot off the press in Nat. Prod. Rep. 2014; 31: 706–10

43. Zhengxi Hu, Jianping Wang, Xiaobin Bi, Jinwen Zhang, Yongbo Xue(*), Yingda Yang, Zengwei Luo, Guangmin Yao, Yonghui Zhang(*): Colletotrichumine A, a novel indole–pyrazine alkaloid with an unprecedented C16N3-type skeleton from cultures of Colletotrichum capsici. Tetrahedron Lett. 2014; 55(44): 6093–5. DOI: 10.1016/j.tetlet.2014.09.041. (JCR2014IF 2.379)

44. Zheng-Xi Hu(#), Yongbo Xue(#), Xiao-Bin Bi, Jin-Wen Zhang, Zeng-Wei Luo, Xiao-Nian Li, Guang-Min Yao, Jian-Ping Wang(*), Yong-Hui Zhang(*): Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii. Mar. Drugs 2014; 12(11): 5563–75. DOI: 10.3390/md12115563. (JCR2014IF 2.853)

45. Yongbo Xue(*), Ye Wu, Hucheng Zhu, Xiao-Nian Li, Jin-Fu Qian, Yongji Lai, Chunmei Chen, Guangmin Yao, Zengwei Luo, Yan Li, Yonghui Zhang(*): Salviprzols A and B, C21- and C22-terpenoids from the roots of Salvia przewalskii Maxim. Fitoterapia 2014; 99: 204–10. DOI: 10.1016/j.fitote.2014.09.022. (JCR2014IF 2.345)

46. Chunmei Chen, Guangzheng Wei, Hucheng Zhu, Yi Guo, Xiao-Nian Li, Jinwen Zhang, Yanfei Liu, Guangmin Yao, Zengwei Luo, Yongbo Xue(*), and Yonghui Zhang(*): A new 3,4-seco-oleanane-type triterpenoid with an unusual enedione moiety from Hypericum ascyron. Fitoterapia 2015; 103: 227-30. DOI: 10.1016/j.fitote.2015.04.009. (JCR2015IF 2.408)

47. Hu-Cheng Zhu(#), Chun-Mei Chen(#), Jin-Wen Zhang, Yi Guo, Dong-Dong Tan, Guang-Zheng Wei, Jing Yang, Jian-Ping Wang, Zeng-Wei Luo, Yong-Bo Xue(*), and Yong-Hui Zhang(*): Hyperisampsins N and O, Two New Benzoylated Phloroglucinol Derivatives from Hypericum sampsonii. Chinese Chem. Lett. 2016; Ahead of print. (JCR2015IF 1.947)

◇ Abstracted by Cheminform 11/2016; 47(47). DOI:10.1002/chin.201647217

48. Hucheng Zhu(#), Chunmei Chen(#), Jianping Wang, Xiao-Nian Li, Guangzheng Wei, Yi Guo, Guangmin Yao, Zengwei Luo, Jinwen Zhang, Yongbo Xue(*), Yonghui Zhang(*): Penicamedine A, a highly oxygenated hexacyclic indole alkaloid from Penicillium camemberti. Chem. Biodiversity. 2015; 12: 1547−53. DOI: 10.1002/cbdv.201400412.

49. Zhengxi Hu, Yongji Lai, Jinwen Zhang, Ye Wu, Zengwei Luo, Guangmin Yao, Yongbo Xue(*), Yonghui Zhang(*): Phytochemical and chemotaxonomic studies on Phyllanthus urinaria. Biochem. System. Ecol. 2014; 56: 60–4. DOI: 10.1016/j.bse.2014.04.016.

50. Junfen Zeng(#), Yongbo Xue(#), Yongji Lai, Guangmin Yao, Zengwei Luo, Yonghui Zhang, and Jinwen Zhang(*): A new phenolic glycoside from the barks of Cinnamomum cassia. Molecules 09/2014; 19(11): 17727–34. DOI: 10.3390/molecules191117727.

51. Ying Tang, Yongbo Xue, Lei Zhou, Jin-Wen Zhang, Guang-Min Yao, Zeng-Wei Luo, Guang Du(*), Yong-Hui Zhang(*): New Norclerodane Diterpenoids from the Tubers of Dioscorea bulbifera. Chem. Pharm. Bull. 2014; 62(7): 719–24. DOI: 10.1002/chin.201452192.

◇ Abstracted by Cheminform 2014; 45(52): DOI: 10.1002/chin.201452192

52. Yongbo Xue, Yan-Long Zhang, Jian-Hong Yang, Xue Du, Jian-Xin Pu(*), Wei Zhao, Xiao-Nian Li, Wei-Lie Xiao, Han-Dong Sun(*): Nortriterpenoids and lignans from the fruit of Schisandra chinensis. Chem. Pharm. Bull. 2010; 58(12): 1606–11. DOI: 10.1002/chin.201118171.

◇ Abstracted by Cheminform 12/2010; 58(12). DOI:10.1002/chin.201118171

Courses Taught

◇ 514.507: Methods and Principles in Natural Medicinal Chemistry

◇ 1002271: Medicinal Chemistry of Natural Products

◇ 1002132: Spectroscopy of Organic Compounds

Working Papers

Awards and Honors

Courses Taught

◇ 514.507: Methods and Principles in Natural Medicinal Chemistry

◇ 1002271: Medicinal Chemistry of Natural Products

◇ 1002132: Spectroscopy of Organic Compounds

Project

◇ Investigation for the discovery of novel anti-Alzheimer’s disease agents from Hypericum plants and their potential mechanisms of action through BACE1/GSK-3β and related signaling pathways (NSFC 81641129, 2017.1-2017.12).

◇ Studies on the chemical constituents and Bioactivities of Phyllanthus species from Huazhong Area (NSFC 31200258, 2013.1-2015.12).

◇ The Fundamental Research Fund for the Central Universities (Nos. 2012QN012, 2014QN128, and 2016YXMS149)

◇ Hubei Provincial Natural Science Foundation of China (2012FFB02333)

◇ The Visiting Scholarship Program of the China Scholarship Council (No. 201606165021)

◇ Scientific Research Foundation of the Huazhong University of Science and Technology (HUST0124514026)

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