Natural Medicinal Chemistry

Natural Medicinal Chemistry is the science of using modern scientific theories and methods to study the chemical constituents of natural medicine. The course is focused on the bioactive chemical components of natural products, which could be used to cure or prevent diseases. The main content of this course contains the fundamental knowledge and theory of the structures, physical and chemical properties, extraction and isolation methods, identification methods, biosynthetic pathway, structural modification, structure-function relationships of the active compounds in the natural products.

The teaching task of this course is to cultivate students' ability to engage in the production and research of natural products. It is a compulsory professional course to the pharmacy students. This course need class 118 hours totally, which includes 64 class hours lectures and 48 class hours experiment training.

Chapter 1st Introduction (12 class hours)

Purpose and requirements:

1. To master the meaning of Natural Medicinal Chemistry and the research tasks, the main biosynthetic pathway of Natural Products, and the extraction methods of Natural Products.

2. To understand the main spectral analysis methods and their uses on structural elucidation of natural products.

Content:

The meaning of Natural Medicinal Chemistry and the research tasks; The main biosynthetic pathway of Natural Products; The extraction methods of Natural Products; The main spectral analysis methods and their uses on structural elucidation of natural products.

Chapter 2nd Alkaloids (10 class hours)

Purpose and requirements:

1. To master the definition, solubility and representative compounds of alkaloids, the relationships between the molecular structures and physical, chemical properties of alkaloids, the definition and influence factors of the basicity of alkaloids and pH gradient extraction.

2. To be familiar with the classification, the identification method of alkaloids; the extraction and isolation method of alkaloids.

3. To understand the biosynthetic pathways of natural occurring alkaloids

Content:

Introduction of the discovery of natural occurring alkaloid and its definition, the biosynthetic pathways of alkaloids and their distributions, the existing forms of alkaloids and naming rule of alkaloids. The classification, physical and chemical properties, extraction and isolation methods, bioactivity of natural alkaloids.

Chapter 3th Saccharides and glycosides (4 class hours)

Purpose and requirements:

1. To master the structural characteristics and classification of saccharides and glycosides, the connection between solubility and molecular structure of glycosides, the reaction mechanism and application for detection of saccharides and glycosides and general approach to extract and isolation polysaccharides and glycosides.

2. To be familiar with some key names and terms of saccharides, the definition of glycosides.

3. To understand different reactivity of every kinds of hydroxyl in monosaccharide, the optical properties and contributions to structural research, the determination methods for sugar chain structure and glycosidic bond configuration.

Content:

The classification of saccharide, the stereochemistry of monosaccharide, the physical and chemical properties, extraction, isolation and structural identification of saccharide. The definition and classification, physical and chemical properties, extraction, isolation and structural research, bioactivity of glycosides.

Chapter 4th Flavonoids (8 class hours)

Purpose and requirements:

1. To master the definition, main physical and chemical properties, representative compounds and determination method of flavonoids.

2. To be familiar with the classification of flavonoids and applications of polyamide column chromatography to separate flavonoids.

3. To understand the extraction and isolation method, bioactivity of flavonoids.

Content:

The definition, Structural classification, physical and chemical properties, extraction and isolation method, determination and structural identification, bioactivity of flavonoids.

Chapter 5th Phenylpropanoid (4 class hours)

Purpose and requirements:

1. To master the definition and representative compounds of phenylpropanoid, cumarin and lignan, the physical and chemical properties of cumarins.

2. To be familiar with the classification of cumarins.

3. To understand the classification of phenylpropanoid and lignan, the physical and chemical properties, the extraction and isolation method, bioactivity of lignin.

Content:

The definition, classification, physical and chemical properties, extraction and isolation method, bioactivity of phenylpropanoid, cumarin and lignan.

Chapter 6th Quinones (6 class hours)

Purpose and requirements:

1. To master the definition, classification, representative compounds, physical and chemical properties of quinones.

2. To be familiar with the extraction and isolation method of quinones.

3. To understand the bioactivity of quinones.

Content:

The definition, classification, physical and chemical properties, extraction and isolation method, bioactivity of quinones.

Chapter 7th Terpenoids (10 class hours)

Purpose and requirements:

1. To master definition, structural characteristics and representative compounds, physical & chemical properties of terpenoids and the methods of separating terpenoids.

2. To be familiar with classification and biosyntheticpathway of terpenoids.

3. To understand the bioactivity of terpenoids.

Content:

The definition, classification, main representatives of terpenoids (such as menthol, gardenoside, artemisinin, andrographolide, ginkgolide, taxol, Oleanolic acid), physical and chemical properties, extraction and isolation methods and bioactivity of terpenoids.

Chapter 8 th Steriods and glycosides (8 class hours)

Purpose and requirements:

1. To master the structural features and classification of steriods;the physical and chemical properties, the extraction method of cardiac glycosides.

2. To be familiar with the color reaction methods of the steroid nucleus and the differences with that of triterpenoids;the structural features of cardiac glycosides;the methods to differentiate types A and B cardiac glycosides;the structural features and division of steroid glycosides aglycones.

3. To understand the steroid components such as pregnane steroids, phytoecdysones, phytosterols, cholic acids;the extraction method of cardiac glycosides.

Content:

The structural features and classification of steriods;Summary and biosynthesis of cardiac glycosides. The chemical structures, the physical and chemical properties, hydrolysis, color reaction, extraction and isolation, spectroscopic features, and bioactivities of cardiac glycosides. The chemical structures, color reaction, extraction and isolation, and spectroscopic features of steroid glycosides aglycones. Introduction to other steroids components.

Chapter 9th Research and Development of Natural Medicines

(2 class hours)

Purpose and requirements:

1. To master the research methods and development procedures of natural medicines.

2. To be familiar with the discovery path natural medicines.

3. To understand the research trends of natural medicines.

Content:

The status of natural medicines research and development in China and in the world;research methods and development procedures of natural medicines;discovery path natural medicines;the research trends of natural medicines.