Liu Xiqiu

Dr. Xi-Qiu LIU, Associate Professor

Email:xiqiuliu@hust.edu.cn

Research interests:In vitro disease models, Drug screening techniques, Biomimetic materials

Curriculum Vitae

Education:

• Ph.D. in Biomaterials, 2012, University of Science and Technology of China, China

  Graduated withChinese Academy of Sciences President Award(top 1% in China)

• B.S. in Biology, 2007, University of Science and Technology of China, China

  Professional Experience:

• Associate Professor (December 2016 - Current): Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

• Research Fellow (April 2013 - December 2016):National Center for Scientific Research in France (CNRS), Grenoble, France;Fellowship fromthe Association Recherche contre le Cancer (ARC) of France

• Post-Doctoral Researcher (October 2012 - March 2013): Grenoble Institute of Technology, Grenoble, France;Adviser:Prof. Catherine PICART

  Scientific Productions

  Paper publications (as the first/corresponding author):

1. Tang R.Z., Liu Z.Z., Gu S.S., andLIU X.Q.*; Multiple Local Therapeutics Based on Nano-Hydrogel Composites in Breast Cancer Treatment.Journal of Materials Chemistry B, 2021, 9, 1521 – 1535

2. LIU X.Q.,Chen X.T., Liu Z.Z., Gu S.S., He L.J., Wang K.P. and Tang R.Z.*; Biomimetic Matrix Stiffness Modulates Hepatocellular Carcinoma Malignant Phenotypes and Macrophage Polarization through Multiple Modes of Mechanical Feedbacks.ACS Biomaterials Science & Engineering, 2020, 6, 3994−4004

3. Tang R.Z., Gu S.S., Chen X.T., He L.J., Wang K.P. andLIU X.Q.*;Immobilized Transforming Growth Factor-Beta 1 in a Stiffness-Tunable Artificial Extracellular Matrix Enhances Mechanotransduction in the Epithelial Mesenchymal Transition of Hepatocellular Carcinoma.ACS Applied Materials & Interfaces, 2019, 11, 14660-14671

4. LIU X.Q.*and Tang R.Z.; Localized delivery of chemokine for in vitro manipulation of hepatocellular carcinoma cell behaviors during the epithelial–mesenchymal transition.Journal of Biomaterials Applications, 2018, 32, 945–956.

5. LIU X.Q.*and Tang R.Z.; Biological responses to nanomaterials: understanding nano-bio effects on cell behaviors.Drug Delivery, 2017, 24, 1-15.

6. LIU X.Q.*, Fourel L., Dalonneau F., Sadir R., Lortat-Jacob H., Weidenhaupt M., Albiges-Rizo C., and Picart C.*; Biomaterial-enabled delivery of SDF-1α at the ventral side of breast cancer cells reveals a crosstalk between cell receptors to promote the invasive phenotype.Biomaterials,2017, 127, 61-74.

7. LIU X.Q.*, Picart C.*; Layer-by-layer assemblies for cancer research and treatments,Advanced Materials, 2016, 28, 1295–1301.

8. Dalonneau F.,LIU X.Q.(co-first author),Sadir R., Almodovar J., Mertani HC., Albiges-Rizo C., Bruckert F., Weidenhaupt M., Lortat-Jacob H., and Picart C.*; The effect of delivering the chemokine SDF-1α in a matrix-bound manner on myogenesis.Biomaterials,2014, 35, 4525–4535.

9. LIU X.Q., Sun C.Y., Yang X.Z., and Wang J.*; Polymeric-micelle-based nanomedicine for siRNA delivery.Particle & Particle Systems Characterization,2013,30, 211-228.

10. LIUX.Q., Xiong M.H., Shu X.T., Tang RZ., andWang J.*; Therapeutic delivery of siRNA silencing HIF-1 Alpha with micellar nanoparticles inhibits hypoxic tumor growth.Molecular Pharmaceutics,2012, 9, 2863-2874.

11. LIU X.Q., Song W.J., Sun T.M., Zhang P.Z., Wang J.*; Targeted delivery of antisense inhibitor of miRNA for antiangiogenesis therapy using cRGD-functionalized nanoparticles.Molecular Pharmaceutics,2011, 8, 250-259.

12. LIU X.Q., Du, J.Z., Zhang C.P., Zhao F., Yang X.Z., and Wang J.*;Brush-shaped polycation with poly(ethylenimine)-b-poly(ethylene glycol) side chains as highly efficient gene delivery vector.International Journal of Pharmaceutics,2010, 392, 118-126.

13. Wang Y.C.,LIU X.Q.(co-first author),Sun T.M., Xiong M.H., and Wang J.*;Functionalized micelles from block copolymer of polyphosphoester and poly(e-caprolactone) for receptor-mediated drug delivery.Journal of Controlled Release,2008, 128, 32-40.

    Book chapters:

14. LIU X.Q.,Yang X.Z., and Wang J.*;“Chapter 7Polymeric micelle-based nanomedicine for siRNA delivery”Functional Polymers for Nanomedicine, Royal Society of Chemistry, 2013

Grants in charge:

1. National Natural Science Foundation of China (No. 82072083), Fabrication of a 3D printed bone metastatic niche model for studying phenotypes and molecular mechanisms in the mesenchymal-epithelial transformation of cancer cells, 2021-2024,￥560,000

2. National Natural Science Foundation of China (No. 81803108), Dynamic models with tunable stiffness and growth factor for study of cell behaviors and molecular mechanisms of hepatocellular carcinoma, 2019-2021,￥210,000

3. The Fundamental Research Fund for the Central Universities (No. 2018KFYYXJJ023), In vitro fabrication of a tunable extracellular matrix model to study cellular behaviors and drug responses of hepatocellular carcinoma, 2018-2020,￥80,000

4. Natural Science Foundation of Hubei Province (No. 2018CFB113), In vitro study of the mechanical environment on cell behaviors and drug responses, 2018-2019,￥50,000

5. The Talent Starting Grant from Huazhong University of Science and Technology in China, In vitro cell microenvironment construction and study of biological functions at interfaces, 2016-2022,￥500,000

   Patents:

   1. An insect living observation device, Chinese patents, No. 202021727386.3 (Authorized)

   2. A polysaccharide compound for long-term inhibition of tumor recurrence after surgery,Chinese patents, Application No. 202110212027.7